ea0014oc9.5 | Signal transduction | ECE2007
Peverelli Erika
, Mantovani Giovanna
, Lania Andrea G
, Calebiro Davide
, Doni Andrea1
, Bondioni Sara
, Beck-Peccoz Paolo
, Spada Anna
Somatostatin (SS) is a widely distributed polypeptide that exerts inhibitory effects on hormone secretion and cell proliferation by interacting with five different receptors (SST1-SST5), that display important differences in tissue distribution, coupling to second messengers, affinity for SS and intracellular trafficking. SS analogues currently used in the treatment of acromegaly inhibit hormone secretion and cell proliferation by binding to SST2 and 5. Beta-arrestins have bee...