Searchable abstracts of presentations at key conferences in endocrinology

ea0014oc11.2 | Reproductive endocrinology II | ECE2007

Leukemia inhibitory factor promotes the chemomigration of immature GnRH neurons

Dozio Elena , Ruscica Massimiliano , Cariboni Anna , Watanobe Hajime , Motta Marcella , Maggi Roberto , Magni Paolo

Leukemia inhibitory factor (LIF), a pleiotropic cytokine of the interleukine-6 superfamily, is involved in several functions including the control of reproduction at the embrionic-endometrial interface and the regulation of energy homeostasis. LIF activates a cell-surface receptor complex (LIF-Rs) composed of one ligand-specific low affinity LIF receptor ╬▓ (LIFR╬▓) subunit and the gp130 subunit. Since little is known about the involvement of LIF in the modulation of t...

ea0014p114 | (1) | ECE2007

Somatostatin and dopamine receptor regulation and effects of a new somatostatin/dopamine chimeric compound on cell proliferation of the human androgen-dependent prostate cancer cell line LNCaP

Arvigo Marica , Ruscica Massimiliano , Dozio Elena , Culler Michael D , Minuto Francesco , Motta Marcella , Magni Paolo , Ferone Diego

The increasing use of somatostatin (SRIF) analogues prompted extensive investigations on SRIF receptor (SSR) in human tumours. Human prostate cancer (PCa) may differentially express SSRs from the normal tissue. Moreover, SSR and dopamine (D) receptors (DR) may interact to form homo- and heterodimers with enhanced functional activity. In the present study, using the human androgen-dependent PCa cell line LNCaP, we investigated: 1) SSR and DR subtype expression in different cult...

ea0014p115 | (1) | ECE2007

Somatostatin receptor regulation and effects of somatostatin and somatostatin analogues on cell proliferation of the human androgen-dependent prostate cancer cell line LNCaP

Ruscica Massimiliano , Arvigo Marica , Dozio Elena , Culler Michael D , Minuto Francesco , Motta Marcella , Ferone Diego , Magni Paolo

Somatostatin (SRIF) has been demonstrated to inhibit in vitro proliferation of normal and transformed cells via SRIF receptors (SSRs). Moreover, like other neuroendocrine molecules, SRIF and SSRs may play a significant role in the progression and neuroendocrine differentiation of human prostate cancer (PCa). However, conflicting results have been reported in the literature on SSR heterogeneity and specific cell localization in PCa. In the present study, using the human ...

ea0035p766 | Obesity | ECE2014

Vertebral bone marrow fat is increased in obese women: relationship with epicardial fat

Ermetici Federica , Briganti Silvia , Delnevo Alessandra , Cannao Paola , Secchi Francesco , Leo Gianni Di , Bandera Francesco , Dozio Elena , Romanelli Massimiliano Marco Corsi , Sardanelli Francesco , Morricone Lelio , Malavazos Alexis Elias

Introduction: Bone marrow fat is considered a risk factor for osteoporosis and fragility fracture. It is not clear if bone marrow adiposity is increased in obesity and how it relates to other compartments of adipose tissue, in particular visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and epicardial adipose tissue (EAT).Aim: To evaluate bone marrow adiposity in obese as compared with normal weight women.Design: Tw...