Searchable abstracts of presentations at key conferences in endocrinology

ea0022p758 | Thyroid | ECE2010

Increased frequency of the glucocorticoid receptor gene polymorphisms in patients with autoimmune thyroid diseases

Antic Jadranka , Petakov Milan , Ognjanovic Sanja , Dragicevic Neda , Lakocevic Milan , Damjanovic Svetozar

Background: Glucocorticoids (GCs) have an important modulatory influence on immune system. GCs accomplish their effects on target tissue through binding to the glucocorticoid receptor (GR). Alterations in glucocorticoid signaling due to polymorphisms of the GR gene may have an impact on the pathophysiology of autoimmune disorders.Aims/methods: We examined the presence of BclI, N363S, A3669G and ER22/23EK GR gene variants in patients with autoimmun...