Searchable abstracts of presentations at key conferences in endocrinology

ea0019p50 | Clinical practice/governance and case reports | SFEBES2009

Hypomagnesaemia and hypocalcaemia with proton-pump inhibitors: an under-recognised phenomenon

Druce MR , Thomas JDJ , Gorrigan RJ , Kelly PA , Coppack SW , Akker SA

Objectives: We describe three patients recently admitted to our institution with severe hypomagnesaemia and hypocalcaemia and a history of proton pump inhibitor (PPI) therapy.Patient 1 was admitted with lethargy, anorexia and leg cramps. Medications included a PPI (omeprazole) prescribed for gastritis. Corrected calcium was 1.54 mmol/l (2.15–2.65) and magnesium 0.25 mmol/l (0.7–1.0), with a PTH of 1.0 pmol/l (1.6–6.9) and 25-OH-vitamin D 5...

ea0008oc10 | Neuroendocrinology and Reproduction | SFE2004

Subcutaneous administration of ghrelin and its effects on food intake in man

Druce MR , Neary NM , Monteiro M , Small C , Ghatei M , Bloom SR

The gastric hormone ghrelin increases appetite and energy intake when administered by intravenous infusion to human subjects and has recently been reported to increase energy intake in patients with anorexia of cancer. Ghrelin also stimulates growth hormone release. We have now investigated whether subcutaneous administration of ghrelin is effective. Approval of the local ethics committee was obtained. Following a preliminary dose-finding study, 16 lean healthy volunteers rece...

ea0008p71 | Neuroendocrinology and behaviour | SFE2004

Ghrelin increases food intake in obese as well as lean subjects

Druce MR , Wren AM , Park A , Milton J , Patterson M , Frost G , Ghatei M , Small C , Bloom SR

The gut hormone ghrelin is involved in feeding behaviour. It increases appetite and food intake when administered by intravenous infusion to subjects of normal weight. Ghrelin levels are often lower in obese than lean individuals and whether responsiveness to ghrelin differs in lean and obese people is not known. We investigated whether obese human subjects are sensitive to the effects of ghrelin. Approval of the local ethics committee was obtained. We examined the effects of ...