Searchable abstracts of presentations at key conferences in endocrinology

ea0070aep721 | Pituitary and Neuroendocrinology | ECE2020

Septo-optic dysplasia with late-onset diagnosis: An uncommon presentation of a rare disease

Duarte Vitória , Ivo Catarina , Veríssimo David , Franco Sara , Bastos Filipa , Marcelino Mafalda , Vara Luiz Henrique , Portugal Jorge

Background: Septo-optic dysplasia (SOD), also known as de-Morsier syndrome, is a rare congenital disorder characterized by any combination of optic nerve hypoplasia, pituitary dysfunction and midline abnormalities of the brain. Clinical diagnosis requires the presence of at least two of the features. This disorder is equally prevalent in males and females, with a reported incidence of 1/10,000 live births. There is wide variation in the severity of the clinical features found....

ea0070ep269 | Endocrine-related Cancer | ECE2020

Multiple endocrine neoplasia: A case series of 7 families

Duarte Vitória , Ivo Catarina , Veríssimo David , Marcelino Mafalda , Vara Luiz Henrique , Franco Sara , Bastos Filipa , Manita Isabel , Raimundo Luisa , Portugal Jorge

Introduction: Multiple endocrine neoplasia (MEN) is a rare genetic syndrome characterized by occurrence of tumors involving two or more endocrine glands. Four types are described: MEN1, MEN2, MEN3 and the recently identi&#-1279;ed MEN4. Due to the complexity of the syndromes, it is difficult to manage these patients. Our objective was to describe the clinical features of individuals from 7 families with a diagnosis of MEN1 or MEN2 and identify current challenges in clinical pr...

ea0070ep499 | Thyroid | ECE2020

Endocrinopathies related to immune checkpoint inhibition: A clinical case presentation

Veríssimo David , Jácome de Castro Matilde , Ivo Catarina , Duarte Vitória , Marcelino Mafalda , Jácome de Castro João

Introduction: In the area of Immunotherapy, immunological checkpoints, such as CTLA-4, PD-1 or PD-L1, are membrane proteins involved in the immune response that, when inhibited, cause an increase in T cell activity and a consequent anti-tumor effect. However, this inhibition can also cause adverse effects, including endocrinopathies, such as thyroid dysfunction and hypophysitis.Clinical case: 59-year-old man, diagnosed with lung cancer, treated with nivo...

ea0073pep7.7 | Presented ePosters 7: Diabetes, Obesity, Metabolism and Nutrition | ECE2021

The impact of dipper profile on diabetes complications. A study of 197 diabetic patients

Duarte Vitória , Ivo Catarina , Veríssimo David , Silva Joao , Lopes Luis , Passos Dolores , Jácome Castro J , Marcelino Mafalda

BackgroundNon-dipping of nocturnal blood pressure is common among people with type 2 diabetes (T2D) and hypertension. Although the mechanism underlying the blunted nighttime response is unclear, insulin resistance is thought to play a role.AimsThis study aims to identify the pattern of nocturnal dipping of blood pressure in patients with T2D from a Portuguese population and its association with micro...

ea0070ep264 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Hearing complications in diabetes – A clinical case

Ivo Catarina , Duarte Vitória , Veríssimo David , Silva João , Costa Eurico , Lopes Luís , Passos Dolores , Matos Teresa , Jácome de Castro João , Marcelino Mafalda

Introduction: Malignant or necrotizing external otitis (MEO) is an invasive infection between external auditory canal and skull base. It is more frequent in elderly and in diabetic patients or with compromised immune system. As MEO advance osteomyelitis can developed. It is a severe and potential mortal complication of external otitis (EO).Clinical case: 78 years old man with history of type2 diabetes (good metabolic control) and right ear external otiti...