Searchable abstracts of presentations at key conferences in endocrinology

ea0013p263 | Reproduction | SFEBES2007

EP2-mediated reduction of oxytocin-induced activity in term pregnant human myometrium

Fischer Deborah , Marshall Kay , Duckworth Nicola , Farrar Diane , O’Donovan Peter , Woodward David

Both prostaglandin (PG) E2 and oxytocin are used clinically in the induction of labour. However, the functional co-expression of inhibitory PGE2 receptors (EP2) and contractile oxytocin receptors in lower segment myometrium is not fully understood. The aim of the present study was to elucidate EP2 agonist effects on oxytocin-induced myogenic contractions and to identify their combined action on intracellular calcium (Ca2+)...