Searchable abstracts of presentations at key conferences in endocrinology

ea0099ep438 | Diabetes, Obesity, Metabolism and Nutrition | ECE2024

Obesity-related comorbidities as potential factors influencing features of premature ageing in severely obese patients

Dudek Alicja , Zapała Barbara , Ciszek Karol , Kawa Ilona , Zgliczyński Wojciech , Major Piotr

Background: Obesity poses a considerable threat to health, increasing the likelihood of accompanying conditions such as type 2 diabetes, hypertension, dyslipidemia, and cancer. Ageing results in the accumulation of damaging factors leading to the development of chronic diseases. Inflammation levels, telomere length, level of neurocognitive function, metabolic age serve as acknowledged indicators of biological aging. The prevalence of premature ageing in obesity has been eviden...

ea0090p263 | Late-Breaking | ECE2023

Are severe obese patients aging faster? The impact of severe obesity on different markers of biological age

Dudek Alicja , Zapała Barbara , Tylec Piotr , Ciszek Karol , Cyranka Katarzyna , Zgliczyński Wojciech , Major Piotr

Obesity is defined as a state of chronic low-grade inflammation. It is associated with pro-inflammatory activity of visceral adipose tissue, regarded as a neuroendocrine organ that secretes cytotoxins and other pro-inflammatory factors, impairing metabolic pathways. The corollary of these changes is the risk of developing comorbidities. There are many similarities in the mechanisms of ageing and in obesity. The process of ageing leads to the accumulation of pro-inflammatory fa...