ea0077op4.2 | Metabolism, Obesity and Diabetes | SFEBES2021
Spencer Lewis
, Dimitriadis Georgios K
, Duggirala Aparna
, Bate Danielle
, Davasgaium Allan
, Al-Hasani Wiaam
, D Miras Alexander
, Le Roux Carel
, Vincent Royce P
, Randeva Harpal S
, Tripathi Gyanendra
Background: Growing evidence suggests that hypothalamic lipid sensing plays a key role in controlling food intake, fat deposition and energy balance and that its dysregulation could lead to obesity and type 2 diabetes (T2D). Recent investigations reported that sphingosine-1-phosphate (S1P) is involved in the hypothalamic control of energy homeostasis. Intra-cerebroventricular administration of S1P decreased food intake and increased energy expenditure in rodents.<p class="...