Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep1129 | Female Reproduction | ECE2017

NCAH prevalance with novel CYP21A2 and CYP11B1 mutations in hirsut turkish women

Polat Seher , Karaburgu Sulbiye , Unluhizarci Kursad , Dundar Munis , Ozkul Yusuf , Karaca Zuleyha , Kelestimur Fahrettin

Introduction: Hirsutism affects 5–8% of the whole female population. In most patients, hirsutism is associated with hyperandrogenemia and the most common cause of androgen excess is polycystic ovary syndrome; however, the clinical presentation of non-classical congenital adrenal hyperplasia(NCAH) in females is often indistinguishable from other hyperandrogenic disorders because of common clinical signs with hirsutism and poly cystic ovary syndrome(PCOS).<p class="abst...

ea0016p610 | Reproduction | ECE2008

Quantitative determination of aromatase and 5-α reductase mRNA and polymorphisms in the aromatase and 5-α reductase genes in idiopathic hirsutism

Dundar Munis , Okay Caglayan A , Baysal Nuran Ahu , Tanriverdi Fatih , Ozkul Yusuf , Unluhizarci Kursad , Kelestimur Fahrettin

Objective: Hirsutism, affects between 5% and 10% of women during reproductive age. Hirsutism associated with normal ovulatory function and normal circulating androgen concentrations is defined as idiopathic hirsutism and little information is available regarding the molecular pathogenesis.Aim: Significance of polymorphisms of the genes involved in androgen/oestrogen biosynthesis (SRD5A2,CYP19) and their expressions inmodulating the susceptibility ...

ea0014p10 | (1) | ECE2007

Normalization of serum testosterone level alters local GnRH-II and IL-2R mRNA expression in peripheral lymphocytes in patients with idiopathic hypogonadotrophic hypogonadism (IHH)

Tanriverdi Fatih , Akalin Hilal , Caglayan Okay , Demirkoparan Umit , Ozkul Yusuf , Dundar Munis , Bayram Fahri , Kelestimur Fahrettin

Although the existence of the interaction between sex steroids and immune system is well known, the mechanisms of this interaction are still unclear. Recently a second form of GnRH (GnRH-II) has been described in human, which is significantly expressed in immune tissues suggesting a potential function. In a recent in-vitro study it has been demonstrated that GnRH-II decreases local expression of IL-2R in peripheral lymphocytes (1). However in-vivo interactions of...

ea0037gp.07.05 | Reproduction: Female and other | ECE2015

mRNA expressions of skin steroidogenic enzymes in women with idiopathic hirsutism

Taheri Serpil , Unluhizarci Kursad , Zararsiz Gokmen , Karaburgu Sulbiye , Borlu Murat , Ozgun Tuncay , Karaca Zuleyha , Tanriverdi Fatih , Dundar Munis , Kelestimur Fahrettin

Introduction: The pathogenesis of idiopathic hirsutism (IH) is not clear. On the other hand, human skin possesses all the enzymes necessary for androgen synthesis and catabolism indicating that it is an independent peripheral endocrine organ. Thus, in the present study we aimed to investigate the mRNA expression of aromatase enzyme and the other enzymes having functional roles in the steroidogenic pathway, in freshly obtained skin tissue from subumblical skin and the arm of wo...

ea0016p13 | Adrenal | ECE2008

The prevalence of non-classic adrenal hyperplasia among Tturkish women with hirsutism

Unluhizarci Kursad , Kula Mustafa , Dundar Munis , Tanriverdi Fatih , Israel Shoshana , Colak Ramis , Dokmetas Hatice S , Atmaca Hulusi , Bahceci Mithat , Balci M Kemal , Comlekci Abdurrahman , Akarsu Ersin , Bilen Habip , Erem Cihangir , Kelestimur Fahrettin

Context: The prevalence of NCAH among Turkish women with hirsutism has not been established so far.Objective: To evaluate the prevalences of 21-hydroxylase (21-OHD) and 11-β hydroxylase deficiencies by ACTH stimulation test among hirsute women.Patients and methods: The study population consisted of 285 premenopousal women, aged 16–46 years (mean: 23.2±0.3). All were hirsute and hyperandrogenic. Androgen secreting tum...