Searchable abstracts of presentations at key conferences in endocrinology

ea0065p199 | Metabolism and Obesity | SFEBES2019

Systemic and femoral adipose tissue-specific nontargeted plasma metabolome during acute hypercortisolaemia

Prete Alessandro , Dunn Warwick B , Manolopoulos Konstantinos

Background: Glucocorticoids have pleiotropic metabolic functions and acute glucocorticoid excess causes dramatic disruption of human metabolism. Whether glucocorticoids exert adipose tissue depot-specific effects on the nontargeted metabolome in unknown.Aim: Assess the nontargeted metabolome in the systemic circulation and in femoral adipose tissue-specific blood samples in response to physiological hyperinsulinaemia and acute hypercortisolaemia.<p c...

ea0050oc1.3 | Early Career Oral Communications | SFEBES2017

Antioxidant pathway targeting as a therapeutic approach in adrenocortical carcinoma

Chortis Vasileios , Taylor Angela E. , Doig Craig L. , Meimaridou Eirini , Walsh Mark , Jenkinson Carl , Rodriguez-Blanco Giovanny , Jafri Alisha , Ronchi Cristina , Metherell Louise A. , Hebenstreit Daniel , Dunn Warwick B. , Arlt Wiebke , Foster Paul A.

Adrenocortical Carcinoma (ACC) is an aggressive malignancy with poor response to chemotherapy. Here we evaluated a potential new treatment target for ACC, focusing on the mitochondrial NADPH generator Nicotinamide Nucleotide Transhydrogenase (NNT). NNT has a central role within the mitochondrial antioxidant pathways, protecting cells from oxidative stress. Inactivating NNT mutations lead to isolated primary adrenal insufficiency, suggesting a selective vulnerability of adrenoc...

ea0050oc1.3 | Early Career Oral Communications | SFEBES2017

Antioxidant pathway targeting as a therapeutic approach in adrenocortical carcinoma

Chortis Vasileios , Taylor Angela E. , Doig Craig L. , Meimaridou Eirini , Walsh Mark , Jenkinson Carl , Rodriguez-Blanco Giovanny , Jafri Alisha , Ronchi Cristina , Metherell Louise A. , Hebenstreit Daniel , Dunn Warwick B. , Arlt Wiebke , Foster Paul A.

Adrenocortical Carcinoma (ACC) is an aggressive malignancy with poor response to chemotherapy. Here we evaluated a potential new treatment target for ACC, focusing on the mitochondrial NADPH generator Nicotinamide Nucleotide Transhydrogenase (NNT). NNT has a central role within the mitochondrial antioxidant pathways, protecting cells from oxidative stress. Inactivating NNT mutations lead to isolated primary adrenal insufficiency, suggesting a selective vulnerability of adrenoc...

ea0065oc1.1 | Metabolism and Obesity | SFEBES2019

Intracrine activation of 11-oxygenated androgens by AKR1C3 modulates lipid metabolism in human female adipose tissue

Schiffer Lina , Sinclair Alexandra J , O'Reilly Michael W , Westgate Connar , Mashood Afeefa , Palmer Elliot , Gilligan Lorna C , Singhal Rishi , Taylor Angela E , Dunn Warwick B , Arlt Wiebke , Storbeck Karl-Heinz

Polycystic ovary syndrome (PCOS) affects 10% of women and is associated with an increased risk of type 2 diabetes and fatty liver disease. Androgen excess is an important driver of metabolic risk in PCOS. In adipose tissue from women with PCOS, increased activation of androstenedione (A4) to testosterone (T) by the enzyme AKR1C3 results in systemic lipotoxicity. Recent in-vitro studies also demonstrated that T and 11-ketotestosterone (11KT) activate the androgen recep...

ea0086oc4.4 | Adrenal and Cardiovascular | SFEBES2022

Steroid and global metabolome in benign adrenal tumours with mild autonomous cortisol secretion: analysis by mass spectrometry and machine learning to understand metabolic risk

Prete Alessandro , Abdi Lida , Canducci Marco , Taylor Angela E. , Bancos Irina , Gilligan Lorna C. , Jenkinson Carl , Albors-Zumel Ariadna , van den Brandhof Elina , Zhang Yuanqing , Chortis Vasileios , Tsagarakis Stylianos , Lang Katharina , Macech Magdalena , Delivanis Danae A. , Pupovac Ivana D. , Reimondo Giuseppe , Marina Ljiljana V. , Deutschbein Timo , Balomenaki Maria , O'Reilly Michael W. , Bednarczuk Tomasz , Zhang Catherine D. , Dusek Tina , Diamantopoulos Aristidis , Asia Miriam , Kondracka Agnieszka , Li Dingfeng , Masjkur Jimmy R. , Quinkler Marcus , Ueland Grethe AE. , Conall Dennedy M. , Beuschlein Felix , Tabarin Antoine , Fassnacht Martin , Ivovic Miomira , Terzolo Massimo , Kastelan Darko , Young Jr William F. , Manolopoulos Konstantinos M. , Ambroziak Urszula , Vassiliadi Dimitra A. , Sitch Alice J. , Tino Peter , Biehl Michael , Dunn Warwick B. , Arlt Wiebke

Background: Benign adrenal tumours are found in 3-10% of adults and can be non-functioning (NFAT) or associated with adrenal hormone excess. Analysing 1305 prospectively recruited patients with benign adrenal tumours, we recently demonstrated that 45% had mild autonomous cortisol secretion (MACS), i.e. biochemical cortisol excess without signs of CushingÂ’s syndrome (CS). MACS increases the prevalence and severity of hypertension and type 2 diabetes (Ann Int Med. 2022 Doi:...