Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep615 | Endocrine-Related Cancer | ECE2022

Frequency of CYP1B1 gene polymorphism in obese and non-obese women with hormone-dependent endometrial cancer

Ilic Dusan , Ognjanovic Sanja , Popovic Bojana , Elezovic Valentina , Opalic Milica , Radic Lena , P. Macut Djuro

Aim: There is a significant link between the increased activity of estrogen and its metabolites in endometrial carcinogenesis. Polymorphisms of the gene involved in metabolism of estrogen can modulate risk for the development of endometrial cancer. CYP1B1 plays an important role in estrogen metabolism. In our study, the frequency of three CYP1B1 gene polymorphisms (4326 C> G, 4390 A> G and 355 G> T) were studied in obese and non-obese women with endometrio...

ea0081rc13.4 | Rapid Communications 13: Adrenal and Cardiovascular Endocrinology 2 | ECE2022

Analysis of the body composition and glucose metabolism in relation to bcli glucocorticoid receptor polymorphism in women with adrenal incidentalomas

Ognjanovic Sanja , Popovic Bojana , Ilic Dusan , Elezovic Valentina , Antic Jadranka , Opalic Milica , Radic Lena , Macut Djuro P

Single nucleotide polymorphisms in the glucocorticoid receptor (GR) gene influence tissue sensitivity of GR. Several studies have shown different effects of BclI GR polymorphism on body composition and metabolic parameters. The objective of this study was to explore the effect of BclI GR polymorphism on the body composition and glucose metabolism. Biochemical tests and hormonal evaluation were performed in 106 consecutive women with adrenal incidentalomas (AI...

ea0081p665 | Pituitary and Neuroendocrinology | ECE2022

Long-term follow up after remission of Cushing’s disease - experience of a single centre

Popovic Bojana , Ognjanovic Sanja , Ilic Dusan , Elezovic Valentina , Opalic Milica , Radic Lena , Milicevic Mihailo , Macut Djuro P.

Introduction: Chronic endogenous hypercortisolism in Cushing’s syndrome imposes a great clinical burden of comorbidities, some of which might persist even after disease remission. Our aim was to analyze factors that predict long-term comorbidities after surgical remission of Cushing’s disease (CD).Subjects and methods: We retrospectively analyzed 37 patents (91.9% females) aged 39.5±13.9 years (10-70) with diagnosed CD, treated in our inst...

ea0063p567 | Diabetes, Obesity and Metabolism 2 | ECE2019

Cardiovascular risk in obese women with polycystic ovary syndrome using Framingham scoring system

Ilic Dusan , Bozic Antic Ivana , Popovic Bojana , Bogavac Tamara , Isailovic Tatjana , Elezovic Kovacevic Valentina , Ognjanovic Sanja , Macut Djuro

Objectives: Women with polycystic ovary syndrome (PCOS) are at increased risk for cardiovascular disease. Aim of our study was to determine the frequency of cardiovascular risk factors using Framingham Scoring system (FSS) in PCOS and controls.Methods: FFS included age, value of cholesterol and HDL (mmol/L), smoking and systolic blood pressure (sysBP, mmHg). We also determined LDL (mmol/l), oxidized LDL (OxLDL, U/l) and triglycerides (mmol/l). We studied...

ea0049gp140 | Female Reproduction | ECE2017

Nonalcoholic fatty liver disease liver fat score (NAFLD-LFS) could be used for the assessment of NAFLD in women with PCOS

Bjekic-Macut Jelica , Bozic-Antic Ivana , Tziomalos Konstantinos , Ilic Dusan , Vojnovic-Milutinovic Danijela , Stanojlovic Olivera , Macut Djuro

Introduction: A relation between polycystic ovary syndrome (PCOS) and nonalcoholic fatty liver disease (NAFLD) was demonstrated recently. Both NAFLD and PCOS are associated with increased risk for type 2 diabetes and cardiovascular disease. NAFLD liver fat score (NAFLD-LFS) has been implicated as a non-invasive surrogate marker for NAFLD. The aim of this study was to identify the prevalence of NAFLD in different PCOS phenotypes using NAFLD-LFS.Methods: W...

ea0049ep75 | Adrenal cortex (to include Cushing's) | ECE2017

Body composition in women with Cushing’s syndrome of different etiology

Ilic Dusan , Macut Djuro , Antic Ivana Bozic , Popovic Bojana , Bogavac Tamara , Isailovic Tatjana , Elezovic Valentina , Ognjanovic Sanja , Damjanovic Svetozar

Introduction: Cortisol has important roles in the regulation of body composition and hypercortisolaemia have major impact on body fat distribution. The aim of this study was to analyze differences in adipose tissue distribution in women with Cushing’s disease and Cushing’s syndrome due to adrenal adenoma.Method: We evaluated 12 women with Cushing’s syndrome, six with ACTH secreting pituitary adenomas (Group A) and six with adrenal adenomas...

ea0044p213 | Reproduction | SFEBES2016

The relation of liver enzymes and insulin resistance in women with polycystic ovary syndrome (PCOS)

Macut Djuro , Bozic-Antic Ivana , Tziomalos Konstantinos , Bjekic-Macut Jelica , Ilic Dusan , Vojnovic-Milutinovic Danijela , Stanojlovic Olivera , Panidis Dimitrios

Introduction: There is a link between polycystic ovary syndrome (PCOS) and nonalcoholic fatty liver disease (NAFLD). Here, we analyzed transaminazes and their relation to insulin resistance (IR) in PCOS women.Methods: We analyzed 600 women with PCOS diagnosed using ESHRE/ASRM criteria (age:25.6±5.9 years, BMI: 30.6±6.9 kg/m2), and 125 BMI-matched healthy controls (age: 31.4±5.3 years, BMI: 29.6±6.8 kg/m2). IR was...

ea0041gp20 | Adrenal (1) | ECE2016

Responsiveness to hCG in postmenopausal women with adrenal adenomas

Popovic Bojana , Macut Djuro , Bozic-Antic Ivana , Bogavac Tamara , Ilic Dusan , Isailovic Tatjana , Elezovic Valentina , Ognjanovic Sanja , Damjanovic Svetozar

Introduction: Luteinizning hormone (LH/hCG) responsiveness has been documented in both normal and pathological adrenal glands, but it is unclear whether chronic exposure to LH could affect adrenal function by increasing LH receptor (LHR) expression.Subjects and methods: We studied 12 postmenopausal women with previously documented adrenal tumor. All patients underwent standard hormonal testing for assessment of tumor functionality. Then hCG test was perf...

ea0041ep631 | Endocrine tumours and neoplasia | ECE2016

Clinical characteristics, survival and prognostic factors of patients with adrenocortical carcinoma: a tertiary centre experience

Elezovic Valentina , Macut Djuro , Ognjanovic Sanja , Isailovic Tatjana , Popovic Bojana , Bozic Antic Ivana , Bogavac Tamara , Ilic Dusan , Damjanovic Svetozar

Adrenocortical carcinoma (ACC) is rare malignancy associated with poor prognosis. The aim of this study was to present clinical characteristics and survival of patients with ACC and to analyse the effect of prognostic factors on survival.We retrospectively analysed 69 patients (46 female and 23 males) with pathologically confirmed ACC who were treated in our hospital between January 2005 and December 2015. The median age at diagnosis was 51,0 years (rang...

ea0037gp.06.03 | Reproduction: Female and PCOS | ECE2015

Characteristics of lipid profile in different phenotypes of polycystic ovary syndrome

Bjekic-Macut Jelica , Antic Ivana Bozic , Milutinovic Danijela Vojnovic , Ilic Dusan , Kastratovic-Kotlica Biljana , Stanojlovic Olivera , Andric Zoran , Macut Djuro

Introduction: Dyslipidaemia is a common metabolic derangement in polycystic ovary syndrome (PCOS) and may be represented with different lipid alterations. The aim of this study was to evaluate lipid profile in different PCOS phenotypes.Methods: We evaluated 365 PCOS women (PCOS: 25.05±6.24 kg/m2; 25.48±5.21 years) diagnosed using ESHRE/ASRM criteria and 125 BMI-matched healthy women (controls: 25.41±5.16 kg/m2; 30.35&...