Searchable abstracts of presentations at key conferences in endocrinology

ea0056mte8 | (1) | ECE2018

Hormone replacement for the travelling patient

Dusek Tina

Millions of people travel across time zones every day for business and for pleasure. Travel-related health issues arise from a variety of factors: infections, prolonged limited mobility during travel, and participation in certain activities, such as diving and high-altitude hiking during travel. Besides that, air travel allows individuals to traverse time zones faster than the internal clock, or circadian rhythm, can adjust. This results in desynchrony between the external lig...

ea0049ep81 | Adrenal cortex (to include Cushing's) | ECE2017

Long term follow up of patients with adrenal incidentaloma and ‘autonomous cortisol secretion’

Kraljevic Ivana , Solak Mirsala , Dusek Tina , Polovina Tanja Skoric , Balasko Annemarie , Kastelan Darko

The aim of this study was to compare the long-term co-morbidities and biochemical data between patients with adrenal incidentaloma and ‘autonomous cortisol secretion’ who were treated surgically and conservatively.Methods: The research of the database of the patients with adrenal incidentaloma diagnosed between 2007 and 2014 was performed. Among them, 43 patients with ‘autonomous cortisol secretion’ were identified and invited for a f...

ea0041ep931 | Pituitary - Clinical | ECE2016

Diabetes insipidus as a predictor of weight gain in craniopharyngeoma patients

Polovina Tanja Skoric , Kraljevic Ivana , Solak Mirsala , Dusek Tina , Kastelan Darko

Craniopharyngeoma patients have reduced quality of life and increased cardiovascular mortality because of severe obesity present in about 50% of patients. In the present study we analysed postoperative body mass index (BMI) in craniopharyngeoma patients depending on the presence of the diabetes insipidus (DI).We retrospectively analyzed 19 craniopharyngeoma patients (male:female=12:7, age 31.2 years, range 9–67) treated at our Department since 2001....

ea0037ep827 | Pituitary: clinical | ECE2015

Early postoperative basal cortisol level as good predictor of hypothalamic–pituitary–adrenal axis function after transsphenoidal surgery for pituitary tumours

Polovina Tanja Skoric , Solak Mirsala , Kraljevic Ivana , Dusek Tina , Baretic Maja , Kastelan Darko

Accurate assessment of the hypothalamic–pituitary–adrenal (HPA) axis is important for the appropriate management of patients with pituitary tumours after transsphenoidal surgery. The aim of our study was to evaluate the clinical relevance of the early postoperative basal cortisol level in assessing postoperative HPA axis function. We performed a retrospective analysis of 68 patients (male:female=36:32, age 59.5 years, range 21–77) treated by transsphenoidal surg...

ea0032p915 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Bone turnover decreases 6 months after acromegaly remission but still remains higher than in healthy population

Dusek Tina , Kraljevic Ivana , Polovina Tanja Skoric , Baretic Maja , Kastelan Darko

Introduction: The study was designed to assess the effects of remission of acromegaly on bone turnover.Methods: Twenty-eight patients with active acromegaly (14 women; age 48.0±9.8 years) were enrolled in the study. The control group comprised 28 age- and sex-matched healthy individuals. Bone turnover markers (osteocalcin, β-crosslaps, and bone alkaline phosphatase) were measured at enrolment and 6 months after achievement of disease remission....

ea0056p884 | Pituitary - Clinical | ECE2018

Clinical and treatment outcomes in patients with craniopharyngiomas – single center experience

Polovina Tanja Skoric , Solak Mirsala , Kraljevic Ivana , Dusek Tina , Spanovic Nemanja , Balasko Anne-Marie , Kastelan Darko

Craniopharyngiomas are rare and histologically benign tumors that are associated with an unfavourable prognosis and controversial optimal treatment. The aim of this retrospective study was to review clinical presentation, natural history and therapeutic outcomes of patients with craniopharyngiomas treated in a single center between 1995 and 2017. In that period, 38 patients (16 children and 22 adults) were diagnosed with craniopharyngioma. Median age at the time of diagnosis i...

ea0081rc7.1 | Rapid Communications 7: Pituitary and Neuroendocrinology 2 | ECE2022

Does the postoperative dose of hydrocortisone influence the health-related quality of life in patients with cured Cushing syndrome?

Kraljevic Ivana , Barac Anja , Solak Mirsala , Skoric Polovina Tanja , Balasko Annemarie , Zibar Tomsic Karin , Dusek Tina , Kastelan Darko

Objective: Patients with Cushing syndrome (CS) have impaired health-related quality of life (HRQoL) before and after surgery. The data on the optimal hydrocortisone dose after surgical cure of CS is scarce. Therefore, we investigated the influence of hydrocortisone dose on HRQoL after surgical treatment of CS. We hypothesized that patients who receive higher hydrocortisone doses after surgery would have better HRQoL and fewer cortisol withdrawal symptoms.<p class="abstext"...

ea0063p1092 | Pituitary and Neuroendocrinology 3 | ECE2019

Factors predicting dopamine agonist treatment withdrawal in prolactinoma patients

Solak Mirsala , Haxhiu Arta , Haxhiu Arita , Kraljevic Ivana , Dusek Tina , Leskovar Dunja , Polovina Tanja Skoric , Balasko Annemarie , Kastelan Darko

Aim: Dopamine agonist (DA) therapy is recommended as first-line treatment for prolactinomas, albeit with long treatment duration and high recurrence rate after treatment withdrawal. The aim of this retrospective study was to evaluate predictors for successful DA withdrawal.Methods: The study included 59 prolactinoma patients (39 female, 20 male; age 34 (18–82) years) that were treated with DA (35.6% on cabergoline); the duration of treatment was 71 ...

ea0049ep71 | Adrenal cortex (to include Cushing's) | ECE2017

Neutrophil-lymphocyte and platelet-lymphocyte ratios as biomarkers in distinguishing adrenocortical adenomas and carcinomas

Solak Mirsala , Kraljevic Ivana , Kastelan Marko , Kakarigi Luka , Dusek Tina , Polovina Tanja Skoric , Balasko Annemarie , Knezevic Nikola , Kastelan Darko

The role of systemic inflammation in promoting tumor progression has been a topic of increasing interest. Neutrophil-lymphocyte ratio (NLR) >5 and platelet-lymphocyte ratio (PLR) >190 used as indicators of inflammation have been reported to have prognostic value in numerous solid tumors. The aim of this retrospective study was to investigate NLR and PLR as biomarkers in distinguishing between adrenocortical adenomas and adrenocortical carcinomas (ACC). Nineteen patient...

ea0037ep817 | Pituitary: clinical | ECE2015

Management of Cushing's disease: single centre experience

Solak Mirsala , Kraljevic Ivana , Dusek Tina , Melada Ante , Kavanagh Marcel Marjanovic , Peterkovic Vjerislav , Ozretic David , Kastelan Darko

Introduction: Cushing’s disease (CD) is an uncommon condition of excess endogenous glucocorticoids caused by ACTH secreting pituitary corticotroph adenoma. The purpose of this study is to review therapeutic outcomes and comorbidity of patients with CD in a single centre.Methods: We conducted a retrospective study of 33 patients with CD undergoing transsphenoidal surgery from January 2007 to February 2014. (27 female and six male, median age 38 years...