Searchable abstracts of presentations at key conferences in endocrinology

ea0086op3.4 | Reproductive and Neuroendocrinology | SFEBES2022

Identification and characterisation of novel follicle-stimulating hormone receptor antagonists

Duyen Tran Hanh , Agwuegbo Uche , Albert Anthony , Jonas Kim

Follicle-stimulating hormone receptor (FSHR) is a Class A G protein-coupled receptor (GCPR) that is essential in reproduction. Interactions with its heterodimeric glycoprotein hormone, FSH, activates the cAMP/PKA signalling pathway, which induces steroidogenic activity and granulosa cell proliferation to support ovarian follicle growth and survival. Moreover, a number of ageing-related extragonadal roles of FSH/FSHR have been proposed, with menopausal elevation in FSH linked t...