Searchable abstracts of presentations at key conferences in endocrinology

ea0022p352 | Diabetes | ECE2010

TCF7L2 gene variants and polycystic ovary syndrome

Vankova Marketa , Vcelak Josef , Lukasova Petra , Bradnova Olga , Prazakova Silva , Dvorakova Katerina , Vrbikova Jana , Bendlova Bela

Polycystic ovary syndrome (PCOS) is considered as a risk factor for diabetes type 2 (DM2), it is often associated with obesity, β-cell dysfunction or insulin resistance. Genetic factors underlying the association of PCOS with DM2 is unknown. Recent human genetic studies have revealed that transcription factor 7-like (TCF7L2) polymorphisms are associated with DM2 through modulation of β-cell function.The aim of this study was to test if <...

ea0020p667 | Reproduction | ECE2009

Selected cytokines are associated with markers of insulin resistance in polycystic ovary syndrome

Stanicka Sona , Vrbikova Jana , Haluzik Martin , Hill Martin , Dvorakova Katerina , Grimmichova Tereza , Vondra Karel

The polycystic ovary syndrome (PCOS) is associated with features of the insulin resistance syndrome and altered glucose homeostasis. Factors that play an important role in these processes are still emerging. Pro-inflammatory cytokines may be involved in development of insulin resistance in PCOS. The purpose of this study was to determine if a relationship exists between interleukin-6 (IL-6), interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1), hepatocyte growth fa...

ea0016p223 | Diabetes and cardiovascular diseases | ECE2008

Glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide in polycystic ovary syndrome

Vrbikova Jana , Hill Martin , Vondra Karel , Bendlova Bela , Grimmichova Tereza , Dvorakova Katerina , Stanicka Sonja , Pacini Giovanni

Insulin hypersecretion during oral or intravenous glucose tolerance test (OGTT, ivGTT) was described previously in women with polycystic ovary syndrome (PCOS). Little attention was given to the regulation of insulin secretion in these subjects. We aimed to study the secretion of incretins (glucose-dependent insulinotropic polypeptide, GIP, glucagon-like peptide 1, GLP-1), during OGTT in normoglucose-tolerant PCOS women.After signing written informed cons...

ea0016p645 | Reproduction | ECE2008

Serum osteoprotegerin in polycystic ovary syndrome

Zajickova Katerina , Hill Martin , Dvorakova Katerina , Stanicka Sona , Vondra Karel , Vrbikova Jana

Osteoprotegerin (OPG) is a potent inhibitor of osteoclastic bone resorption. Besides osteoblasts, OPG is expressed by both endothelial and vascular smooth muscle cells. Moreover, elevated serum OPG has been found in conditions associated with insulin resistance such as obesity, diabetes and/or Cushing syndrome.The aim of the present study was to investigate the relationship between serum OPG and insulin resistance in women with polycystic ovary syndrome ...

ea0014p614 | (1) | ECE2007

Family history of diabetes mellitus determines insulin sensitivity and beta cell dysfunction in polycystic ovary syndrome

Vrbikova Jana , Dvorakova Katerina , Grimmichova Tereza , Hill Martin , Stanicka Sona , Vondra Karel

Aim: To examine the secretion of insulin and glucagon in PCOS in the context of insulin sensitivity.Patients and methods: 13 healthy women (BMI 21.8(2.2) kg/m2), 21 PCOS without family history of DM2 (FH-); BMI 24.3 (4.4) kg/m2 and 16 PCOS with the 1st degree relative affected by DM2 (FH+); BMI 26.7 (4.2) kg/m2. Euglyceamic hyperinsulinaemic clamp (1mIU kg−1.min−1; with the determination ...

ea0014p615 | (1) | ECE2007

Retinol-binding protein-4 in polycystic ovary synrome - relationship with obesity and androgen levels

Vrbikova Jana , Hill Martin , Bendlova Bela , Grimmichova Tereza , Dvorakova Katerina , Vondra Karel

Aim and background: Retinol binding protein 4 (RBP 4) is an adipocyte-secreted molecule causing insulin resistance in transgenic animals. RBP was increased in subjects with impaired glucose tolerance and diabetes type 2. The levels of RBP-4 in PCOS were not investigated till now.Subjects and methods16 lean PCOS (BMI 21.4 (1.75) kg/m2, age 24.1 (4.1) years), 25 obese PCOS (BMI 30.3 (4.8) kg/m2, age 26.3 (5.0) years) and 13 healthy wo...

ea0037gp.18.02 | Pituitary–Basic and IGF-1 | ECE2015

Neuroactive steroids as predictive markers for Alzheimer's disease

Vankova Marketa , Vejrazkova Daniela , Lukasova Petra , Bradnova Olga , Vacinova Gabriela , Dvorakova Katerina , Hill Martin , Vcelak Josef , Rusina Robert , Holmerova Iva , Bendlova Bela

Background and aims: Neuroactive steroids and their metabolites play an important regulatory role in the nervous system affecting the neuronal plasticity, stress response, learning, and memory. The aim of the study was to compare the steroid metabolome in AD patients and controls.Materials and methods: The study comprised of 48 AD patients (30 women and 18 men; age 73.8±9.54 years) and 33 matched controls (22 women and 11 men; age 68.2±5.94 yea...