Searchable abstracts of presentations at key conferences in endocrinology

ea0007oc31 | Diabetes and metabolism | BES2004

Inducing pancreatic beta cell regeneration; interactions of transcription factors and peptide growth factors

Leadbeater W , Thyssen S , Strutt B , Chamson A , Arany E , Pin C , Logan A , Hill D

Pancreatic islet cell transplantation is proven to restore functional beta cell mass to achieve normoglycemia in diabetics, but is limited by low availability of human cadaveric donor tissue. A strategy to build capacity is to use stem cells (SCs), and induce their expansion and differentiation into functional islets in vitro. Islet cell neogenesis has been linked to transient and sequential expression of specific transcription factors (TFs) and the actions of endogenou...