Searchable abstracts of presentations at key conferences in endocrinology

ea0029p1222 | Obesity | ICEECE2012

Visceral-to-subcutaneous fat ratio using fat measurement CT is essential for the assessment of risk for diabetes, hypertension and early atherosclerosis

Kim H. , Bae S. , Kim E. , Kim C.

Background and aims: Obesity is an important risk factor for metabolic and cardiovascular disease. Although body mass index (BMI) and waist circumference are convenient and economic methods for assessment of obesity, those could not fully reflect risk for diabetes, hypertension and early atherosclerosis.Materials and methods: We cross-sectionally analyzed anthropometric and laboratory data of 868 Korean adults (age 53.2±11.2 years) which were record...

ea0029p536 | Diabetes | ICEECE2012

Predictive ability of prediabetes defined by fasting plasma glucose and HbA1c for progression to diabetes in Koreans

Kim C. , Kim H. , Kim E. , Bae S. , Park J.

Background: The predictive ability of prediabetes defined by HbA1c (5.7–6.4%) or fasting plasma glucose (FPG) criteria (5.6–6.9 mmol/l) for the development of diabetes may differ according to ethnic groups, but only limited longitudinal data are available in Asians. We examined the progression rate to diabetes in Korean adults diagnosed as prediabetes according to these two criteria.Methods: We analyzed data of 9432 Korean adults (age 20–7...

ea0029p113 | Adrenal cortex | ICEECE2012

Usefulness of FDG–PET for detecting primary aldosteronism in patient who have bilateral adrenal incidentaloma

Kim Y. , Ko M. , Park C. , Nam-Goong I. , Na Y. , Kim E.

Adrenal masses are common incidental radiological findings. It has been estimated that as many as 10–20% of patients with essential hypertension may suffer from undiagnosed primary aldosteronism (PA). In patients who have both adrenal incidentaloma, which the functioning one must be identified. We report a case where an unilateral PA was detected on 18F-fluorodexoyglucose (FDG)-positron emission tomography (PET), and comfirmed by adrenal venous sampling.<p ...

ea0054p5 | (1) | NuclearReceptors2018

Glucocorticoid receptor inhibits ER-mediated pro-proliferative gene expression

Tonsing-Carter E , Kim CR , Hernandez KM , Bowie KR , West DC , Chandarlapaty S , Greene GL , Conzen SD

Early-stage ER+ breast cancer (BC) with high tumor glucocorticoid receptor (GR) expression is associated with improved long term relapse-free survival compared to tumors with low GR expression. In addition, GR activity inhibits ER-mediated BC cell proliferation. We therefore hypothesized that GR and ER engage in nuclear receptor crosstalk to influence pro-proliferative gene expression, thus contributing to a better outcome in ER+/GR+ breast cancer. To understand the mechanisms...

ea0026p503 | Bone/calcium/Vitamin D | ECE2011

Differential gene expression in Runx2 and osterix double heterozygotes during skeletal development

Baek J E , Kim Y H , Baek W Y , de Crombrugghe B , Choi J Y , Kim J E

The transcription factors Runx2 and osterix (Osx), which are known as downstream genes in BMP2 pathway, are essential for osteoblast differentiation and bone formation. Runx2 expression is normal in Osx null mice, but Osx is not expressed in Runx2 null mice, indicating that Osx acts as a downstream of Runx2. Here, we questioned whether or not all bones could be formed by BMP2–Runx2–Osx pathway or unknown their own gene axis. To answer this question, we first analyzed...