Searchable abstracts of presentations at key conferences in endocrinology

ea0013p165 | Diabetes, metabolism and cardiovascular | SFEBES2007

Bone marrow stem cells differentiating along the adipogenic lineage show marked up regulation of the adenosine A1 receptor transcript

Easter Tammy , Lewis B Mary , Elford Carole , Ludgate Marian , Ham Jack , Evans Bronwen , Scanlon Maurice , Lewis Mark

Bone marrow stem cells (BMSCs) are able to differentiate along multiple lineages including adipogenic and osteogenic lineages. The adenosine A1 receptor (A1R) modulates adipose tissue function causing an inhibition of lipolysis. We therefore studied A1R expression in BMSCs induced to differentiate along the adipogenic lineage.BMSCs were isolated from rat femur (10 wk male Wistar), cultured in control medium (alphaMEM 10% FCS) and then plated into adipocy...