Searchable abstracts of presentations at key conferences in endocrinology

ea0011s39 | Stromal cell-matrix interactions | ECE2006

Hormonal regulation of mesenchymal stem cell differentiation in bone

Jakob Franz , Seefried Lothar , Schütze Norbert , Ebert Regina

Mesenchymal Stem Cells (MSC) are the source of regeneration of musculoskeletal tissues. Stem cells (SC) are rare and slowly dividing cells, situated in stem cell niches, regulated by non-stem-cell cap cells. Rare symmetric SC division regulates the SC pool. Asymmetric cell division gives rise to a transient amplifying pool (MSCTAP). The MSC niche is poorly characterized in contrast to MSCTAP and consecutive events of fate decision, commitment and secretio...