ea0003p158 | Genetics | BES2002
Draper N
, Echwald S
, Sorensen T
, Astrup A
, Lavery G
, Chalder S
, Hewison M
, Pedersen O
, Stewart P
11beta-hydroxysteroid dehydrogenase regulates glucocorticoid action, by interconverting cortisone (E) to cortisol (F). The Type 1 isozyme (11betaHSD1) is an oxoreductase expressed in adipose tissue, where it may play a role in the pathogenesis of visceral obesity.We have characterised two polymorphic (CA)n microsatellite markers within intron 4 of the HSD11B1 gene, termed (CA)15 and (CA)19. In an earlier study evaluating a 'normal' population (MONICA co...