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Endocrine Abstracts

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ea0090oc10.2 | Oral Communications 10: Diabetes, Obesity, Metabolism and Nutrition 2 | ECE2023

Characterization of the insulinotropic and glucose lowering actions of hybridized amphibian host defence peptide, tigerinin-1R

Abiodun Falobi Ayodele , Edeani Joy Nneka , Ofosu Wendy Amy , Smyth Lesley , Corcoran Olivia , Dunmore Simon , Ojo Opeolu

Aim: Our previous studies indicated the potential antidiabetic actions of the amphibian host-defence peptide, tigerinin-1. Tigerinin-1R was conjugated with gastric inhibitory polypeptide (GIP) as part of strategies for further development of its therapeutic effects. This study characterises the insulin-releasing and cytotoxic properties of the resulting hybrid peptide.Method: Pure G-TGN was commercially synthesized G-TGN. Insulin releasing effects were a...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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