Searchable abstracts of presentations at key conferences in endocrinology

ea0084ps1-04-34 | Thyroid Hormone Transporters and Development | ETA2022

The dawning of deiodinases: an outer ring deiodinase activity in the social amoeba dictyostelium discoideum with high affinity for reverse t3

Meima Marcel , Schaap Pauline , Edward Visser W.

Background: Conservation of genes involved in TH transport, metabolism and action can reveal clues about the origins of TH signaling. A deiodinase homologue (DdDio) was previously identified in the social amoeba Dictyostelium discoideum (Singh, 2014). Dictyostelium cells live as single cell amoebae in soil where they feed on bacteria. However, upon starvation a developmental program is initiated that results in the formation of a multicellular fruiti...

ea0084ps1-04-31 | Thyroid Hormone Transporters and Development | ETA2022

The role of type 3 deiodinase in a human model for early brain development

Lopez Marti Anna , Gunhanlar Nilhan , Meima Marcel , Edward Visser W.

Background: Disrupted thyroid hormone (TH) homeostasis has devastating effects on human neurodevelopment. THs are critical signaling molecules in neurodevelopment, acting on differentiation of neural cells, migration, synaptogenesis and myelination, with deiodinases governing intracellular TH concentrations in a spatiotemporal manner. It is remarkable that fetal neural cells, while being key target cells of TH, exhibit strong activity of the TH inactivating enzyme DIO3. Curren...

ea0084op-02-11 | Oral Session 2: Pregnancy | ETA2022

Association of thyroid function and tpoab positivity with the risk of postpartum depression: A population-based cohort study, systematic review, and meta-analysis

Sileo Federica , Osinga Joris , Edward Visser W. , Derakhshan Arash , Citterio Valeria , Persani Luca , Korevaar Tim

Background: Postpartum depression (PPD) is a common mental health disorder with a major impact on maternal health and wellbeing and offspring development. Thyroperoxidase antibody (TPOAb) positivity is a major risk factor for postpartum thyroiditis and via this link, it is hypothesized that TPOAb positivity is a risk factor for PPD. However, the results of currently available single center studies are heterogeneous and affected by major study limitations.<p class="abstext"...

ea0084ps1-04-36 | Thyroid Hormone Transporters and Development | ETA2022

Thyroid hormone signaling in a human cellular model for early brain development

Gunhanlar Nilhan , Tellez Garcia Juan , Lopez Marti Anna , Shokrollahi Faezeh , Meima Marcel , Edward Visser W.

Background and Objective: Disrupted thyroid hormone (TH) signaling has devastating effects on human neurodevelopment. The molecular mechanisms underlying TH regulation and action are largely based on animal models. However, animal models are limited in revealing some of the most fundamental aspects of neurodevelopment that are unique to humans. We employed human induced pluripotent stem cell (iPSC) technology to study the effects of T3 on neurodevelopmental processes in a huma...

ea0092ps2-17-04 | Thyroid Cancer Diagnosis 2 | ETA2023

PRO-gastrin-releasing peptide as an additional screening marker in the diagnostic work up for medullary thyroid carcinoma

Schonebaum Leonoor , van Balkum Mathe , Edward Visser W. , van den Berg Sjoerd , Peeters Robin

Background: Patients with medullary thyroid carcinoma (MTC), a neuroendocrine tumour derived from the parafollicular C-cells, often present with metastasized disease. Survival strongly correlates with stage of disease at diagnosis, illustrating the need for early diagnosis. Calcitonin (CT), a well-established tumour marker for MTC, is limited by a high rate of false positives in the screening phase. Promising new markers for MTC are procalcitonin (PCT) and progastrin releasin...

ea0092ps2-20-09 | Thyroid hormone receptors basic | ETA2023

The relevance of histidine 175 in thyroid hormone receptor alpha 1 for co-repressor binding revealed by a family carrying a H175R variant

Liao Wenjun , Meima Marcel , Groeneweg Stefan , Hannema Sabine , Edward Visser W.

Background: Resistance to thyroid hormone (TH) alpha (RTHα), caused by heterozygous mutations in THRA, is characterized by abnormal thyroid function tests and features due to tissue-specific hypothyroidism, including disproportional short stature, variable motor and cognitive defects, macrocephaly and macroglossia, constipation and anemia. Mutant receptors display defective T3 binding resulting in impaired transcriptional activity. Dominant negative inhibition of the WT r...

ea0092ps3-30-01 | Thyroid Physiology in Periphery &amp; Development Basic | ETA2023

Developing an animal-free testing battery for thyroid hormone related developmental neurotoxicity

Dierichs Nathalie , Meima Marcel , Edward Visser W. , Piersma Aldert , Hessel Ellen , Peeters Robin

Background: Over the last few decades, in vivo animal experiments have been the gold standard for the assessment of safety of chemicals and pharmaceuticals for human health. However, in vivo animal data has limited relevance for toxicity prediction in humans, especially considering species-specific issues of age, sex and exposure in different life-stages. Within the Virtual Human Platform for Safety Assessment (VHP4Safety) project we aim to develop an animal-...

ea0092op-10-01 | Oral Session 10: Novel diagnostics in Thyroid cancer | ETA2023

Identification of clinical and histopathological risk factors for radioactive iodine refractory disease in patients with follicular and hurthle cell thyroid carcinoma

Stegenga Merel , Oudijk Lindsey , Van Velsen Evert , Medici Marco , Peeters Robin , Edward Visser W. , van Kemenade Folkert

Introduction: Historically, treatment of follicular thyroid carcinoma (FTC) and oncocytic thyroid carcinoma (OTC) is based on thyroidectomy followed by radioiodine (RAI) therapy. Both tumor types have a good prognosis (10-year survival 80-94%), but this changes significantly once RAI-refractory disease occurs (median 3.5 years), which limits further treatment possibilities. The main risk factors for developing RAI-refractory disease in FTC and OTC are unknown. Our aim was to i...

ea0092op-11-05 | Oral Session 11: Autoimmunity / Hyperthyroidism | ETA2023

Association between thyroid function and osteoarthritis: a population-based cohort study

Xu Yanning , Szilagyi Ingrid , Boer Cindy , Sedaghati-Khayat Bahar , Edward Visser W. , van Meurs Joyce , Chaker Layal

Background: Previous genetic and animal studies implied a potential association between thyroid hormone and osteoarthritis (OA), but this has not been confirmed in the general population. We aim to investigate whether thyroid function is associated with hand, hip or knee OA.Methods: We included 9,054 participants from Rotterdam Study with baseline measurement of thyroid-stimulating hormone (TSH), free thyroxine (FT4) and radiographs. Joint radiographs we...

ea0084ps2-09-84 | Thyroid Hormone ACTION | ETA2022

Molecular mechanisms underlying action of triac in resistance to thyroid hormone BETA (RTHβ)

Liao Wenjun , van Geest Ferdy , Marelli Federica , Campi Irene , Moran Carla , Lyons Greta , Agostini Maura , Peeters Robin , Chatterjee Krishna , Persani Luca , Meima Marcel , Edward Visser W.

Background: Resistance to thyroid hormone (TH) beta (RTHβ), caused by mutations in THRB, is characterized by elevated serum (F)T4 accompanied by non-suppressed TSH concentrations. Disease features arise from variable resistance to TH action in tissues expressing Thyroid Hormone Receptor (TR) β (hypothalamus, pituitary, liver) and from thyrotoxic effects in tissues expressing TRα (heart, bone, brain). In symptomatic patients, treatment mainly involves be...