Endocrine Abstracts

Brown adipose tissue (BAT) may directly dissipate energy into heat and is associlated with a metabolically favorable phenotype. Cold exposure activates BAT via the sympathetic nervous system and its transmitter norepinephrine. In rodents, the activation is facilitated by the β3-adrenoreceptor (β3-AR). In humans treatment with the β3-AR agonist mirabegon leads to a rather weak activation of BAT as compared to a cold stimulus. In vitro studies in cell lines from h...