Endocrine Abstracts

Scattered case reports have described patients who have been diagnosed with both primary hyperaldosteronism and prolactinoma. Prolactin receptor (PRLR) is known to be expressed in human adrenal cortex. Furthermore, PRLR mRNA and protein have both been detected in human adrenal tumors. It has also been shown that PRL treatment of adrenal cells is capable of stimulating aldosterone secretion. The contribution of PRL to the development of hyperaldosteronism is u...

Ketogenic low-carbohydrate/high fat diets (LC-HFD) induce weight loss in both animals and humans. However, a number of unwanted side effects with these diets have been reported. We have previously shown in male rats that LC-HFDs negatively affect bone growth and bone mineral density, possibly due to macronutrient-induced impairments of the GH/IGF-system. Given the importance of dietary macronutrients in the regulation of bone density in male rats, in this study we investigated...