Searchable abstracts of presentations at key conferences in endocrinology

ea0067o44 | Oral Presentations | EYES2019

Quality of life in chronic hypoparathyroidism

Kovaleva Elena V , Mokrysheva Natalia G.

Introduction: Reduced health-related quality of life (HRQoL) is common in patients with chronic hypoparathyroidism treated conventionally with active vitamin D and calcium supplements.Aim: To determine the HRQoL of patients with hypoparathyroidism with disease persisting for more than 1 year.Methods: We identified 32 patients (women/men − 31/1, median (Me) age 48 years [38; 59.5]). The average duration of the disease was 4 ye...

ea0063gp21 | Calcium and Bone 1 | ECE2019

The long-term outcomes of chronic post-surgical hypoparathyroidism

Mokrysheva Natalia , Eremkina Anna , Kovaleva Elena

Hypoparathyroidism (HP) is a rare disease characterized by an absence or inappropriately low concentrations of circulating parathyroid hormone, leading to hypocalcaemia, hypophosphatemia and elevated urinary calcium excretion.Aim: To determine complications in chronic post-surgical HP patients.Material and methods: We have analyzed the data from 76 patients (71 women and 5 men; median age 51.8 years (range 18–77)) with chronic...

ea0081ep132 | Calcium and Bone | ECE2022

Association of preoperative therapy by native form vitamin D and hypocalcemia after parathyroidectomy in primary hyperparathyroidism patients

Elfimova Alina , Eremkina Anna , Rebrova Olga , Kovaleva Elena , Mokrysheva Natalia

Background: Primary hyperparathyroidism (PHPT) is a common endocrine disorder resulting from oversecretion of parathyroid hormone (PTH) in parathyroid glands. Hypocalcemia can occur in the postoperative period after parathyroidectomy (PTE) and can be challenging to control and requires varying doses of supplementation. Vitamin D deficiency can worsen the severity of PHPT and promote the development of “hungry bone syndrome” due to increased influx of calcium into bon...

ea0081ep146 | Calcium and Bone | ECE2022

Quality of life in chronic hypoparathyroidism on conventional treatment

Gins Nikolay , Elfimova Alina , Kovaleva Elena , Eremkina Anna , Mokrysheva Natalia

Introduction: Reduced health-related quality of life (HRQoL) is common in patients with hypoparathyroidism (HypoPT) treated conventionally with calcium and active vitamin D supplements.Aim: we studied the HRQoL in patients with chronic HypoPT estimated with the 36-Item Short-Form Health Survey (SF-36) and multidimensional fatigue inventory (MFI-20).Methods: 64 patients with chronic HypoPT (women/men – 57/7, median age 47[36;59...

ea0090ep142 | Calcium and Bone | ECE2023

Chronic hypoparathyroidism: Predictors of complications according to the Russian Registry

Kovaleva Elena , Elfimova Alina , Eremkina Anna , Mokrysheva Natalia

Background: Chronic hypoparathyroidism is a relatively rare disease associated with various complications. The analysis of large databases of patients with chronic hypoparathyroidism is a necessary tool to enhance quality of medical care, as well as to determine the therapeutic approaches and prognostic markers of the disease.Aims: To describe complications associated with chronic hypoparathyroidism and determine predictors of their development according...

ea0049ep257 | Calcium & Vitamin D metabolism | ECE2017

Normocalcemic versus Hypercalcemic Primary Hyperparathyroidism: a comparative study

Mokrysheva Natalya , Mirnaya Svetlana , Eremkina Anna , Krupinova Julia , Kovaleva Elena

Introduction: Normocalcemic primary hyperparathyroidism (NPHPT) is defined as a condition in which persistently normal serum calcium levels are observed in the presence of high levels of parathyroid hormone (PTH). NPHPT is a new entity which possibly represents a clinically symptomatic disease and which has generated a considerable scientific interest.Aim: To compare the clinical and laboratory data between the normocalcemic and hypercalcemic forms of PH...

ea0070ep74 | Bone and Calcium | ECE2020

Clinical case: Complicated differential diagnosis between postsurgical and functional hypoparathyroidism.

Kovaleva Elena , Eremkina Anna , Krupinova Julia , Mokrysheva Natalia

Objective: Postsurgical hypoparathyroidism (HypoPT) is the most common etiology of disease and often occurs after thyroid surgery. However, the differential diagnosis between different forms of HypoPT in some cases remains a challenge. We present the clinical case of postsurgical and functional HypoPT combination.Case description: A 44-year-old female was referred to the Endocrinology Research Centre. She underwent total thyroidectomy for follicular aden...

ea0073aep124 | Calcium and Bone | ECE2021

The natural history of hypoparathyroidism according to the database of endocrinology research centre

Kovaleva Elena , Eremkina Anna , Aynetdinova Alina , Mokrysheva Natalia

BackgroundHypoparathyroidism is a rare disorder characterized by hypocalcemia and hyperphosphatemia due to absent or inadequate parathyroid hormone secretion. Data on effective treatment strategies and predictors of long-term complications have only recently began to emerge. The epidemiological information regarding chronic hypoparathyroidism in Russia is strictly limited that prompted this research.AimsTo es...

ea0073ep22 | Calcium and Bone | ECE2021

Deficiency or insufficiency of vitamin D and the frequency of hypocalcemia episodes and the circadian rhythm of serum calcium level

Kovaleva Elena , Eremkina Anna , Aynetdinova Alina , Mokrysheva Natalia

IntroductionVitamin D deficiency is considered as a major public health concern. Due to vitamin D’s crucial role in the intestinal calcium absorption, its deficiency may result in hypocalcemia and in a spectrum of associated clinical manifestations.AimTo assess the effect of 25(OH) vitamin D level (25(OH)D) on the frequency of hypocalcemia episodes and the daily profile of serum calcium and 24-h urinary ...

ea0081ep137 | Calcium and Bone | ECE2022

Glomerular filtration rate 12 months after parathyroidectomy in patients with primary hyperparathyroidism

Elfimova Alina , Eremkina Anna , Rebrova Olga , Kovaleva Elena , Miliutina Anastasia , Mokrysheva Natalia

Background: In some patients with primary hyperparathyroidism (PHPT), glomerular filtration rate (GFR) demonstrate decrease after parathyroidectomy (PTE). GFR may decrease immediately after surgery due to general anesthesia, but after a month not all patients restore kidney function; a decreased GFR is also observed after 1–2 years after surgery.Aim: To find the pre-surgical factors of GFR decrease after PTE.Methods: Patients ...