Searchable abstracts of presentations at key conferences in endocrinology

ea0026s18.2 | Management of endocrine disease in pregnancy | ECE2011

Type 2 diabetes and pregnancy

Anastasiou Eleni

Obesity and DM2 increasingly affect young adults worldwide, to the point of warranting the description of ‘epidemic’. This means that greater numbers of women of reproductive age are at risk. Frequently DM2 remains undiagnosed until pregnancy. The rate of congenital malformations seems to be the same with that of women with DM1, but the rate of perinatal mortality appears to be increased, according to a recent meta-analysis. These findings occur despite the fact that...

ea0049gp230 | Thyroid Cancer | ECE2017

Radioiodine (RAI) refractory differentiated thyroid cancer (DTC): outcome and prognostic factors for DISEASE progression

Saltiki Katerina , Simeakis George , Anagnostou Elli , Apostolakis Michalis , Zapanti Evangelia , Anastasiou Eleni , Alevizaki Maria

Introduction: Patients diagnosed with DTC have excellent prognosis. A small percentage of patients with disease persistence do not respond to treatment with RAI (RAI-refractory DTC) and have low median survival (3.5 years). We investigated the prognostic factors and the disease course in patients with RAI-refractory DTC.Methods: Of all DTC patients (n=1160) followed-up in our department in recent years, 800 received RAI treatment and were classified in 2...

ea0037gp.23.08 | Thyroid – diagnosis | ECE2015

Clinical characteristics in sporadic and familial medullary thyroid carcinomas: worse outcome in sporadic cases even when disease stage at diagnosis is similar

Saltiki Katerina , Spanou Loukia , Kouki Sofia , Rentziou Gianna , Vasileiou Vasiliki , Anastasiou Eleni , Alevizaki Maria

Objectives: Medullary thyroid carcinoma (MTC) has varying clinical course with familial cases (fMTC) diagnosed earlier than sporadic ones (sMTC). We examined the presentation of these entities in our centre.Methods: 223 MTC patients (familial: 42.6%, males: 36.8%) were followed for 0.9–30 years (mean 6.23±5.9, median 4.0 years). 44 (19.7%) fMTC patients were operated after genetic screening.Results: Median age at diagnosi...

ea0032p1085 | Thyroid cancer | ECE2013

Pre-existing autoimmune thyroid disease may influence the course of the disease in differentiated thyroid carcinoma patients

Athanasiadou Anastasia , Saltiki Katerina , Rentziou Gianna , Papageorgiou George , Anastasiou Eleni , Alevizaki Maria

Introduction: Differentiated thyroid carcinoma (DTC) has generally a good prognosis and is associated with prolonged survival. A minority of patients may have persistent disease and rarely aggravation during f/u. We investigated factors which may influence the persistence of disease in patients who had undergone ablation with I131.Patients and methods: 903 DTC patients were referred in our center from 1968 to 2012. Five hundred and forty-one (...

ea0032p1121 | Thyroid cancer | ECE2013

Clinical and biochemical criteria for the prognosis of small medullary thyroid carcinomas

Saltiki Katerina , Rentziou Gianna , Vasileiou Vasiliki , Athanasiadou Anastasia , Anastasiou Eleni , Alevizaki Maria

Introduction: Recently, small medullary thyroid carcinomas (sMTCs) (≤1.5 cm) are frequently diagnosed, occasionally as incidental findings in surgical and autopsy specimens. Their clinical course varies. We examined whether tumor size is a predictor of clinical behavior.Patients and methods: One hundred and one sMTC patients (36.6% males, 47.1% familial) followed-up for 0.9–35 years. Patients were classified according to tumor size (cm) in gro...

ea0022p315 | Diabetes | ECE2010

Vitamin D deficiency and isolated fasting hyperglycemia in pregnancy

Vasileiou Vasiliki , Athanasiadou Anastasia , Giakoumi Athanasia , Papageorgiou George , Zapanti Evangelia , Alevizaki Maria , Anastasiou Eleni

Introduction: The relation between vitamin D deficiency and gestational diabetes mellitus (GDM) has been rarely addressed in the literature with conflicting results. The aim is to determine the association between maternal serum 25(OH)D and glucose metabolism in Caucasian pregnant women.Patients and methods: In a prospective study 157 pregnant women aged 31.2±5.8 years underwent a 100 g OGTT in the third trimester of pregnancy, during which serum 25...

ea0022p478 | Female reproduction | ECE2010

The polymorphic Alu1 variant of ERβ may modulate the feedback regulation of LH secretion

Saltiki Katerina , Mantzou Emily , Anastasiou Eleni , Pappa Theodora , Huhtaniemi Ilpo , Alevizaki Maria

A common polymorphism of the ERβ gene (AluI) located in 3′-UTR of exon 8 has been shown to be associated with clinical features of altered estrogen action in tissues where this gene is expressed. It has recently been shown that GnRH neurons express ERβ, indicating that this receptor may participate in the feedback regulation of gonadotrophin secretion. We therefore studied the association of gonadotrophin levels and the AluI polymorp...

ea0056gp264 | Thyroid non cancer - Autoimmune Thyroid disease/pregnancy | ECE2018

Thyroid function in pregnant women; relation to Gestational Diabetes Mellitus (GDM) and Body Mass Index (BMI)

Simeakis George , Vogiatzi Evangelia , Konstantakou Panagiota , Zapanti Evangelia , Saltiki Katerina , Alevizaki Maria , Anastasiou Eleni

Objectives: The interplay between thyroid function and metabolic state has been studied in many population subgroups. For pregnant women thyroid and metabolic parameters, including glucose homeostasis, are of great importance for a successful outcome. We examined aspects of thyroid function in relation to GDM and BMI in pregnant women referred to our Department.Methods: We studied 520 women during 24th – 32nd gestation week. De...

ea0056p1097 | Thyroid (non-cancer) | ECE2018

Primary thyroidal paraganglioma in a 60 years old female with thyroid goiter

Sapounas Spyridon , Manthakos Christos , Pissia Maria , Saltiki Katerina , Anastasiou Eleni , Zapanti Evangelia

Primary Paraganglioma of Thyroid Gland is an extremely rare neuroendocrine tumor. Less than 50 cases have been reported up to date and its rarity is the reason why it’s often mistaken for thyroid nodule or other thyroid neoplasms. In this case we describe the misleading results of ultrasonography followed by FNA-biopsy, which led to a total delay of two years until final diagnosis. A 60 year old female presented with a 38 mm right-sided thyroid module. An ultrasound guide...

ea0016oc6.5 | Metabolism and cardiovascular | ECE2008

Association of the SHBG gene promoter polymorphism with early markers of atherosclerosis in apparently healthy women

Saltiki Katerina , Voidonikola Paraskevi , Lazaros Leandros , Stamatelopoulos Kimon , Mantzou Emily , Georgiou Ioannis , Anastasiou Eleni , Papamichael Christos , Alevizaki Maria

Objective: Androgen may be detrimental in the development of cardiovascular disease in women. We investigated possible associations between the (TAAAA)n polymorphism of sex hormone binding globulin (SHBG) gene promoter, which influences transcriptional efficiency of the SHBG gene and thus the tissue androgen availability and early markers of atherosclerosis in apparently healthy women.Design and methods: In this prospective clinical study, 153 con...