Endocrine Abstracts

Background: Hormonal disturbances may be encountered in the context of paraneoplastic syndromes. Neuroendocrine tumors (NETs) represent a rare group of cancers, derived from the group of chromaffin cells, thus their paraneoplastic potentials remain relatively unexplored.Case presentation: Middle-aged female presented to the local A&E with psychosis, hyperglycemia, mild hypokalemia. Background includes resected ovarian cancer and chemotherapy before 3...

Introduction: Thyroid storm is a rare condition, reflecting an extreme physiological state within the spectrum of thyrotoxicosis. The disorder consists of the clinical manifestations of thyrotoxicosis in association with altered mental status. On the other hand, excess circulating thyroid hormones are associated with glycemic disorders, like hyperglycemia and insulinopenia. Moreover, diabetic ketoacidosis has been associated with thyroid storm in few cases. We report the case ...

Introduction: Long term treatment with corticosteroids has been widely used, due to the well documented immunosuppressive and anti-inflammatory activity. Corticosteroids are among the most widely prescribed drugs in oncology and post-transplant patients. However, long-term treatment with a dose of corticosteroids, which equals prednisolone 5mg/day for at least 4 weeks, is very likely to result in suppressed function of the hypothalamic pituitary adrenal (HPA) axis, a condition...

Neuromyelitis Optica (NMO) is a neuro-inflammatory condition usually presenting with optic nerve and spinal cord events, caused by autoimmunity to Aquaporin 4 (AQ4) channels in the central nervous system (CNS). The high density of AQ4 channels in the hypothalamus and area postrema mean that NMO can occasionally present with atypical features. We present a 56-year old South Asian man, who presented with hiccoughs and Syndrome of inappropriate antidiuretic hormone (SIADH ) and w...

Introduction: Coexistence of primary hyperparathyroidism and plasma cell dyscrasias such as multiple myeloma and monoclonal gammopathy of uncertain significance (MGUS) is rare. This can cause diagnostic uncertainty regarding the aetiology and relative contribution of each disorder to hypercalcaemia. We present a series of five individuals with this combination.Case series: All five patients were referred to the endocrine clinic with hypercalcaemia. The s...

Background: Resection of the adrenal gland is a challenging intervention that requires close endocrinological supervision for the correct assessment of hormones to minimise complications peri-operatively (peri-op) and post-operatively (post-op).Objectives: This study assessed the function of the hypothalamus–pituitary–adrenal axis and the related management according to underlying adrenal disorders.Methods: We reviewed 16...

Background: A growing body of evidence reports implications of a direct extra-gonadal effect of follicle stimulating hormone (FSH), involving the development of obesity. The aim of this study was to evaluate the associations between traditional and local obesity indices and FSH concentrations in women after menopause.Methods: We evaluated a total of 420 postmenopausal women in a cross-sectional design (age 55.6±6.5 years, BMI were 25.8±4.0 kg/m...

Objective: Aiming to identify individuals with more benign metabolic profile, we explored the link between anthropometric predictors as well as serum levels of sex hormones and phenotypes of metabolic health in non-obese postmenopausal women.Methods: A total of 458 non-obese (BMI <30 kg/m2) postmenopausal women (age 55.2±7.1 years, BMI=24.6±2.8 kg/m2) were retrieved from the Menopause Clinic of Aretaieio Hospital, Nati...

Introduction: Delayed diagnosis of a cardiovascular event is related with higher case-fatality rate in women as compared to men. In fact, accumulating evidence supports an association between the menopausal status and the development of cardiovascular disease (CVD). We aimed to assess the extent of subclinical vascular disorders in young, healthy postmenopausal women, with respect to the calculated cardiovascular risk.Methods: This cross-sectional study ...

Objective: To assess the impact of genetic polymorphisms associated with increased cardiovascular risk on the lipid profile in healthy postmenopausal women.Methods: The study population consisted of 84 women between 49–69 years who had been menopausal for at least one year. The genetic polymorphisms examined were the following: Glycoprotein IIIa leu33pro, Apolipoprotein E2/E3/E4, Methylenotetrahydrofolate reductase ala222val, Apolipoprotein B arg350...