Searchable abstracts of presentations at key conferences in endocrinology

ea0014p286 | (1) | ECE2007

An analysis on delays in diagnosis of papillary thyroid cancer

Dionigi Gianlorenzo , Dionigi Renzo , Bartalena Luigi , Tanda Maria Laura , Piantanida Eliana , Boni Luigi , Rovera Francesca

Background: Thyroid carcinoma represents the most frequent form of cancer of the endocrine glands. In Italy, temporal trend shows a significant increase of incidence rates. Papillary thyroid cancer is the most common thyroid malignancy. Papillary thyroid carcinoma happens to be a multicentric tumor and trends to spread to the lymph nodes in the early stage of the disease. Thus early diagnosis is vital to improve the outcome for patients with thyroid cancer. The aim of this stu...

ea0014p434 | (1) | ECE2007

Amyloid goitre: report of a case

Dionigi Gianlorenzo , Salvadore Maurizio , Tanda Maria Laura , Piantanida Eliana , Villa Francesca

Background: Amyloidosis is an important etiological factor of end stage renal disease. Apart from major target organs as cardiovascular, respiratory and gastrointestinal system, endocrine organs can also be involved. Amyloid goitre was described for the first time by Beckmann in 1858. Approximately 200 cases of amyloid goiter have been reported in English literature.Case presentation: The patient is a 67-year-old woman. The patient referred in 1989 the p...

ea0081p211 | Thyroid | ECE2022

SARS-CoV-2 Vaccine-Associated Subacute Thyroiditis: Insights from a Systematic Review

Ippolito Silvia , Gallo Daniela , Rossini Alessandro , Patera Bohdan , Lanzo Nicola , Fazzino Gaia Francesca Maria , Piantanida Eliana , Laura Tanda Maria

Introduction: subacute thyroiditis (SAT) is an inflammatory disease of the thyroid gland causing transient thyrotoxicosis, characterized by neck pain and symptoms of thyroid hormones excess. Viral infections are considered the main trigger of SAT. SAT has also been described after vaccination against H1 N1 vaccine, seasonal influenza virus vaccine, Human Papillomavirus vaccine, and hepatitis B vaccination; more recently, a rising number of cases of SAT following SARS-CoV-2 vac...

ea0073aep748 | Thyroid | ECE2021

Paraneoplastic hyperthyroidism in hCG-secreting metastatic testicular cancer

Patera Bohdan , Fazzino Gaia , Lanzo Nicola , Lepanto Silvia , Gallo Daniela , Lai Adriana , Piantanida Eliana , Laura Tanda Maria

IntroductionWe report a case of severe thyrotoxicosis due to a metastatic testicular tumor secreting human chorionic gonadotropin (hCG), known to have a TSH-mimicking effect due to alpha-subunits’ structural similarity.Case reportIn November 2020 a 38-year-old man was referred to our Department for thyrotoxicosis of unknown etiology. He had no family history of thyroid disease and his medical history had...

ea0081p557 | Calcium and Bone | ECE2022

Hyperparathyroidism development after oncogenic osteomalacia treatment

Patera Bohdan , Martina Bianchi Federica , Clementi Ilaria , Maria Fazzino Gaia Francesca , Lanzo Nicola , Lepanto Silvia , Manzella La Barbera Francesca , Piantanida Eliana , Tanda Maria Laura

Tumor-induced osteomalacia (TIO) or ‘oncogenic osteomalacia’ is a rare paraneoplastic disorder, usually resulting from Fibroblast Growth Factor 23 (FGF23) oversecretion by a benign small ‘phosphaturic mesenchymal tumor’, causing hypophosphatemia and reduced 1,25-dihydroxyvitamin D synthesis. Calcium and parathyroid hormone (PTH) levels are usually normal, but secondary/tertiary hyperparathyroidism has been reported in up to 5% of the cases, mainly due to 1,...

ea0081ep13 | Adrenal and Cardiovascular Endocrinology | ECE2022

A challenging case of hypertension: an ACTH-secreting pheochromocytoma

Lanzo Nicola , Fazzino Gaia Francesca Maria , La Barbera Francesca Manzella , Patera Bohdan , Lepanto Silvia , Bianchi Federica Martina , Clementi Ilaria , Piantanida Eliana , Tanda Maria Laura

Pheochromocytoma is a rare catecholamine-secreting tumour arising from chromaffin cells in the adrenal medulla and one of the main causes of endocrine hypertension. We here report the case of a 48-year old man admitted to the Internal Medicine Department for evaluation of resistant hypertension. The patient presented with headache, sweating, palpitations, pitting edema, hypertension and hypokalemia both resistant to conventional polytherapy. He was therefore investigated for e...

ea0049ep1451 | Thyroid (non-cancer) | ECE2017

Comparative analysis of clinicopathological characteristics between Korean and Italian thyroid cancer patients

An Jee Hyun , Kim Sin Gon , Kim Hoon Yub , Jung Kwang Yoon , Chae Yang Seok , Dionigi Gianlorenzo , Rausei Stefano , Tanda Maria Laura , Piantanida Eliana , Rosa Stefano La

Background: The incidence of thyroid cancer in South Korea has increased rapidly. Increase in medical surveillance and access to health care services have enhanced the detection of asymptomatic tumors. We investigated the differences of tumor characteristics between South Korean patients and Northern Italian patients subject to different healthcare systems.Methods: The demographic, histopathologic and management features of thyroid cancer operated in two...

ea0081p466 | Thyroid | ECE2022

Predictive factors of success of radiometabolic therapy in Graves’ disease

Gallo Daniela , Mercuriali Anna , Tanzi Fabio , Veronesi Giovanni , Lai Adriana , Ippolito Silvia , Sabatino Jessica , Patera Bohdan , Lepanto Silvia , Lanzo Nicola , Fazzino Gaia , Bianchi Federica , Clementi Ilaria , Manzella Francesca , Tanda Maria Laura , Piantanida Eliana

Aim of the study: recurrence or persistence of hyperthyroidism occur in 15-25% of cases after radioiodine therapy (RAI) in Graves’ disease (GD). Our study aimed to establish prognostic factors affecting RAI outcome and to investigate if a tailored dosimetric approach based on the application of the “effective biological dose” (BED) offered a higher chance of success.Materials and methods: our cohort comprised 365 GD patients (280 women and...

ea0049ep688 | Obesity | ECE2017

Demographic and baseline characteristics of an obese population admitted for bariatric surgery in a secondary care centre

Gallo Daniela , Ippolito Silvia , Veronesi Giovanni , Dozio Eugenia , Frattini Francesco , Trotti Eugenia , Lai Adriana , Sassi Lorenza , Sabatino Jessica , Masiello Elvira , Premoli Paola , Bianconi Eleonora , Cusini Claudio , Rosetti Sara , Tanda Maria Laura , Dionigi Gianlorenzo , Bartalena Luigi , Piantanida Eliana

Obesity has become one of the greatest public health concerns and is known to be a major risk factor for cardiac, respiratory and metabolic diseases. Bariatric surgery is the most effective treatment for morbid obesity. According with guidelines, surgery is indicated for treatment of patients with BMI greater than 40 kg/m2 or above 35 kg/m2, with at least one obesity-related comorbid condition, such as as type 2 diabetes, hypertension, dyslipidemia, sleep...

ea0049ep691 | Obesity | ECE2017

Metabolic profile reversal after bariatric surgery

Gallo Daniela , Ippolito Silvia , Veronesi Giovanni , Dozio Eugenia , Frattini Francesco , Trotti Eugenia , Lai Adriana , Sassi Lorenza , Sabatino Jessica , Masiello Elvira , Premoli Paola , Bianconi Eleonora , Rosetti Sara , Cusini Claudio , Laura Tanda Maria , Dionigi Gianlorenzo , Bartalena Luigi , Piantanida Eliana

Bariatric surgery is the most-effective treatment for morbid obesity, superior to medical treatment. Metabolic syndrome (MS) is a condition characterized by multiple major risk factors for coronary heart disease, diabetes, fatty liver, and several cancers; the main, diagnostic, components of MS are low HDL-cholesterol (<40 mg/dl in man, <50 mg/dl in woman), raised triglycerides (>150 mg/dl), blood pressure >130/85 mmHg, fasting plasma glucose >100 mg/dl and...