Searchable abstracts of presentations at key conferences in endocrinology

ea0014p111 | (1) | ECE2007

RET genotypes comprising specific haplotypes of polymorphic variants are associated with sporadic medullary thyroid cancer

Fugazzola Laura , Muzza Marina , Mian Caterina , Cordella Daniela , Barollo Susi , Cirello Valentina , Elisa Girelli Maria , Opocher Giuseppe , Beck-Peccoz Paolo , Persani Luca

Many single nucleotide polymorphisms (SNPs) of the RET gene have been described both in the general population and in patients with sporadic medullary thyroid cancer (sMTC), MEN2 or Hirschsprung disease. Some association studies reported a higher prevalence of these variants in the affected patients, suggesting a possible role in modifying the risk of occurrence of the disease. However, data from different cohorts of sMTC are discrepant and the aim of the present study ...