Searchable abstracts of presentations at key conferences in endocrinology

ea0065p354 | Reproductive Endocrinology and Biology | SFEBES2019

Maternal cardiovascular risk and pregnancy outcomes in turner syndrome – new evidence supports current guidance

Calanchini Matilde , Bradley-Watson James , Orchard Elizabeth , Turner Helen E

Introduction: The risk of maternal death from aortic-dissection(AoD) during pregnancy/post-partum in TS is increased, due to TS-associated risk factors (bicuspid-aortic-valve(BAV), aortic-coarctation, aortic-dilatation, hypertension) and the increased cardiovascular strain of pregnancy itself. TS-guidelines advice against pregnancy in the presence of severe aortic-dilatation or moderate dilatation with AoD-risk factors; and after aortic surgery a high risk remains. However, fe...

ea0056gp260 | Thyroid non cancer - Autoimmune Thyroid disease/pregnancy | ECE2018

Early low dose rituximab for active thyroid eye disease: an effective and well tolerated treatment

Insull Elizabeth , Turner Helen , David Joel , Norris Jonathan

Background: Thyroid eye disease (TED) is an autoimmune inflammatory disease that can be both disfiguring and potentially sight threatening. Suppression of inflammation in active disease can reduce the risk of visual loss and limit long-term sequelae of the disease. Current disease management involves suppression of inflammation using glucocorticoids. The aim of our study was to evaluate the efficacy of early disease intervention with targeted immunomodulatory therapy to alter ...

ea0044p226 | Reproduction | SFEBES2016

A multidisciplinary specialist team for pregnancy in Turner’s syndrome improves survival and maternal and fetal outcomes

Kumarasinghe Gayathri , Calanchini Matilde , Mackillop Lucy , Weingart Emma , Orchard Elizabeth , Turner Helen

Aims: Turner’s syndrome (TS) is associated with bicuspid aortic valve (BAV), ascending aortic dilatation (AD), aortic coarctation, and hypertension. Pregnancy in TS is associated with increased risk of aortic dissection (2%), gestational hypertension, pre-eclampsia and a 2% risk of maternal mortality.This retrospective study aimed to assess the effectiveness of a multidisciplinary team (MDT) comprising endocrinologist, cardiologist and maternal medi...

ea0044p227 | Reproduction | SFEBES2016

Re-evaluation of safety in pregnancy following oocyte donation in Turner’s Syndrome; is it time to modify the guidelines?

Kumarasinghe Gayathri , Calanchini Matilde , Mackillop Lucy , Weingart Emma , Orchard Elizabeth , Turner Helen

Aims: Oocyte donation (OD) is increasingly utilised in women with Turner’s syndrome (TS). However, guidelines state TS a ‘relative contraindication’ for pregnancy, due to increased risk of aortic dissection (AD 2%) and maternal mortality (2%). Recent data on OD-related morbidity and mortality in TS has raised further concern. We aimed to analyse cardiovascular risk profiles of TS women undergoing OD and those with spontaneous pregnancy (SP), and determine outcom...

ea0041ep663 | Female Reproduction | ECE2016

Pre-pregnancy risk assessment and combined multidisciplinary care improves pregnancy outcomes in women with Turner’s syndrome

Kumarasinghe Gayathri , Calanchini Matilde , Mackillop Lucy , Ormerod Oliver , Manning Nicky , Orchard Elizabeth , Turner Helen

Aims: Women with Turner’s syndrome (TS) are increasingly undertaking pregnancies, either via natural conception (mosaic TS) or assisted conception (AC). Increased TS pregnancies have led to reports suggesting high risk of pregnancy associated aortic dissection (AOD) 2%, and maternal mortality 2% due to underlying aortic valve abnormalities and aortopathies. However, the literature is limited to small case series. We report our practice providing risk-assessment and combin...

ea00100p17 | Poster Presentations | SFEEU2024

‘Don’t forget the eye when seeing thyroid!’

Humayun Khan Huma , Oustabassidis Eva , Norris Jonathan , David Joel , Elizabeth Turner Helen

Case History with Investigations: A 65-year-old female, with no previous thyroid abnormalities, was originally referred to ENT with goitre. She was clinically and biochemically euthyroid, and following ultrasound with fine needle aspiration for right-sided nodules with benign cytology, was discharged. She was subsequently referred to Endocrinology with persistent lethargy and hair loss despite normal thyroid function. She described gritty eyes and swollen eyelids for 2 years, ...