Searchable abstracts of presentations at key conferences in endocrinology

ea0070aep134 | Bone and Calcium | ECE2020

Radiofrequency Echographic Multi Spectrometry (REMS) evaluation in patients with primary osteoporosis and primary hyperparathyroidism

Grassi Giorgia , Palmieri Serena , Cairoli Elisa , Chiodini Iacopo , Arosio Maura , Eller Vainicher Cristina

Background: Radiofrequency Echographic Multi Spectrometry (REMS) is a new ultrasound-based tool for bone mineral density (BMD) measurement, recently approved by FDA for the use in clinical routine to diagnose osteoporosis (OP) and to monitor bone changes. However, data on patients with secondary OP are not available. The aim of our study was to compare REMS and DXA ability in identifying clinical (cFX) and morphometric vertebral fractures (VFx) in patients with primary OP (pOP...

ea0014oc2.3 | Bone & calcium metabolism | ECE2007

Clinical and biochemical differences in patients affected with sporadic and type 1 multiple endocrine neoplasia (MEN) related primary hyperparathyroidism

Eller-Vainicher Cristina , Massironi Sara , Peracchi Maddalena , Persani Luca , Beck-Peccoz Paolo , Spada Anna , Corbetta Sabrina

Primary hyperparathyroidism (PHPT) may occur sporadically or within MEN syndromes. It is classically thought that PHPT in MEN occurs at earlier ages than sporadic PHPT without significant differences in clinical and biochemical presentation. The aim of the study was to compare clinical and biochemical parameters between sporadic PHPT and MEN1 patients. The study included 41 genetically diagnosed MEN1 patients (14M, 27F) and 88 sporadic PHPT patients (24M, 64F) matched for age ...

ea0073oc6.4 | Oral Communications 6: Calcium and Bone | ECE2021

Bisphosphonates after Denosumab withdrawal reduce the vertebral fractures incidence

Grassi Giorgia , Chiodini Iacopo , Palmieri Serena , Cairoli Elisa , Arosio Maura , Eller Vainicher Cristina

ObjectiveSeveral studies showed that patients discontinuing denosumab (Dmab) may experience bone loss and incident vertebral fractures (VFx) due to a rebound bone turnover increase, suggesting the need of anti-resorptive (i.e. bisphosphonate BPs) therapy to mitigate this occurrence. However, the morphometric VFx (morphoVFx) incidence after Dmab discontinuation is unknown and scarce data are available about the BPs effect on BMD changes and Fx risk in thi...

ea0037ep247 | Calcium and Vitamin D metabolism | ECE2015

Clinical and biochemical response to denosumab in a young adult patient with craniofacial fibrous dysplasia

Cairoli Elisa , Eller-Vainicher Cristina , Rossi Diego Sergio , Beltramini Giada Anna , Russillo Antonio , Mantovani Giovanna , Spada Anna , Chiodini Iacopo

We report on the clinical and biochemical outcomes in a 20-year-old male suffering from active craniofacial monostotic fibrous dysplasia (MFD) treated with the RANK-L inhibitor, Denosumab, following unsatisfactory responses to prior long-term bisphosphonates therapy. The patient had been treated over 9 years with pamidronate (cumulative dose of 81 mg), but experienced only mild reductions in pain scores. Following initiation of Denosumab 60 mg subcutaneously, bone pain and bon...

ea0016s20.5 | Translational highlights | ECE2008

V206M polymorphism of the SLC26A6 gene encoding a Cl-oxalate transporter in patients with primary hyperparathyroidism and kidney stones

Corbetta Sabrina , Eller-Vainicher Cristina , Frigerio Marcello , Valaperta Rea , Costa Elena , Vicentini Leonardo , Beck-Peccoz Paolo , Spada Anna

Primary hyperparathyroidism (PHPT) is associated with increased risk of kidney stones. Hypercalciuria and urine oxalate excretion are considered risk factors for urolithiasis in PHPT stone-formers. Recently, the anion-exchanger SLC26A6 has been involved in the oxalate metabolism. Slc26a6-null mice showed hyperoxalemia, hyperoxaluria resulting in dramatic calcium oxalate urolithiasis. We tested the hypothesis that urine oxalate excretion in PHPT patients might be modulat...

ea0016oc4.6 | Bone and adrenal | ECE2008

Isolation and characterization of cells coexpressing endothelial progenitors and parathyroid specific genes from human adult normal and tumoral parathyroids

Corbetta Sabrina , Belicchi Marzia , Pisati Federica , Meregalli Mirella , Eller-Vainicher Cristina , Vicentini Leonardo , Beck-Peccoz Paolo , Spada Anna

A peculiar characteristic of parathyroid tissue is the ability to spontaneously induce angiogenesis, to proliferate and to secrete PTH when autotransplanted in patients undergoing total parathyroidectomy. Since stem/progenitor cells have been involved in the process of tissue regeneration, we searched for putative parathyroid progenitors from human normal and tumoral parathyroids. By immunohistochemistry, FACS analysis and cell culture we identified parathyroid cells positive ...

ea0016p282 | Endocrine tumours | ECE2008

Screening of MEN1 gene in patients with either classic or variant MEN1 presentation

Cordella Daniela , De Marco Alessandro , Eller-Vainicher Cristina , Bastagli Anna , Jaffrain-Rea Marie Lise , Beck-Peccoz Paolo , Persani Luca

Multiple endocrine neoplasia type 1 (MEN1) is a rare dominantly inherited neoplastic syndrome. Tipically, it affects three major locations: parathyroid, endocrine pancreas or duodenum (GEP) and anterior pituitary. MEN1 is caused by mutations in MEN1 gene and its testing is now used as a complement to clinical diagnosis which may be hindered by the variable penetrance and expression of the defects. Mutation carriers are life-long monitored, while unaffected relatives can avoid ...

ea0056p195 | Bone ' Osteoporosis | ECE2018

Cystic fibrosis-related bone disease in young adults affected with cystic fibrosis awaiting lung transplantation for end-stage respiratory failure

Cairoli Elisa , Eller-Vainicher Cristina , D'Adda Alice , Briganti Federica , Pappalettera Maria , Tarsia Paolo , Arosio Maura , Chiodini Iacopo

Background: Cystic fibrosis-related bone disease (CFBD) is an emerging complication of cystic fibrosis (CF), especially in CF-lung transplant candidates for end-stage disease.Objectives: The assessment of vitamin D levels, bone mineral density (BMD) and morphometric and clinical prevalent fragility fractures in a cohort of young adults affected with CF awaiting lung transplantation for end-stage respiratory failure.Methods: In 42 C...

ea0081p307 | Calcium and Bone | ECE2022

Impact of underlying disease on long-term skeletal outcome after lung transplantation

Grassi Giorgia , Chiodini Iacopo , Cairoli Elisa , Corinna Morlacchi Letizia , Rossetti Valeria , Rosso Lorenzo , Righi Ilaria , Nosotti Mario , Arosio Maura , Blasi Francesco , Eller Vainicher Cristina

Background: fragility fractures (FX) occur frequently after lung transplantation (TX), with a higher rate (15-20%) in the first two years, which decreases subsequently. Patients affected from cystic fibrosis (CF) seem to have a lower FX risk in the first two years after TX as compared with those affected with other lung diseases (nCF). The aim of our study is to evaluate and compare the long-term skeletal outcome in CF and nCF patients after TX.Methods: ...

ea0037gp.19.02 | Pituitary–Acromegaly | ECE2015

Assessment of bone quality, measured by trabecular bone score, in acromegaly

Malchiodi Elena , Sala Elisa , Verrua Elisa , Cairoli Elisa , Carosi Giulia , Ferrante Emanuele , Filopanti Marcello , Ulivieri Fabio Massimo , Eller-Vainicher Cristina , Chiodini Iacopo , Mantovani Giovanna , Spada Anna

Introduction: Acromegaly is characterised by chronic exposure to high GH and IGF1 levels that leads to increased bone turnover. Regardless of BMD value, acromegalic patients seem to have an increased vertebral fracture risk probably due to a reduction of bone quality. Trabecular bone score (TBS) is a new index used for assessing bone microarchitecture. In this study TBS was used for the first time to analyze bone quality in acromegaly.Methods: 16 new acr...