Searchable abstracts of presentations at key conferences in endocrinology

ea0031p136 | Cytokines and growth factors | SFEBES2013

Effect of acute hypoxia upon myostatin expression in healthy individuals

Elliott Bradley , Renshaw Derek , Getting Stephen , Watt Peter , Mackenzie Richard

We previously showed acute hypoxic conditions result in atrophy of myotubes in vitro. Chronic hypoxic exposure in vivo induces muscular atrophy in healthy mountaineering individuals and patients with COPD. Myotubes in vitro increase myostatin expression in response to hypoxic exposure. Further, hypoxic COPD patients show cachexia and increased serum myostatin expression. However, in vivo results are cofounded by disease factors in COPD patie...

ea0025p140 | Diabetes, metabolism and cardiovascular | SFEBES2011

Insulin sensitivity and cytokine response to different exercise modalities in hypoxia in type 2 diabetics

Mackenzie Richard , Maxwell Neil , Elliott Bradley , Brickley Gary , Watt Peter

Continuous aerobic exercise improves glucose tolerance in type 2 diabetics (T2D), with greater improvements during exercise in hypoxia. Continuous exercise has been linked with poor adherence. Positive effects with intermittent exercise (IE) with reduced time commitments would have clear benefits. Exercise and hypoxia both increase pro-inflammatory cytokines, potentially reducing benefits of hypoxia. This study aimed to establish the effects of IE under hypoxic conditions in T...

ea0031p191 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2013

Novel inositol pyrophosphate and insulin sensitivity in response to muscle contraction in glucose intolerant humans

Naufahu Jane , Watt Peter , Mellish Louise , Elliott Bradley , Kerekgyarto Anna , Mackenzie Richard

Peripheral insulin resistance is a major defect associated with glucose intolerance and type two diabetes. Yet the mechanism(s) responsible for this defect remain to be determined. Inositol pyrophosphate (IP7) is formed via the enzyme IP6K1 from IP6. The inhibition of Akt, and the potential decrease in insulin signalling, through the binding of IP7 to the Akt PH domain represents an exciting research area.Firstly, we will characterise this mechanism in h...