Searchable abstracts of presentations at key conferences in endocrinology

ea0014p312 | (1) | ECE2007

VEGF, FGF and HGF in differentiated thyroid cancer

Przybylik-Mazurek Elwira , Huszno Bohdan

Pathogenesis of thyroid cancer involves a number of biological, and environmental factors. The growth factors have mitogenic, proliferative and dedifferentiating effects. Some of the cytokines: Vascular Endothelial Growth Factor (VEGF), Fibroblast Growth Factor (FGF), Hepatocyte Growth Factor (HGF) are detected in a neoplasmatic tissue. Moreover, there are affected thyroid cancer cell growth and function in vitro.Aim of the study: The aim of the s...

ea0056p43 | Adrenal cortex (to include Cushing's) | ECE2018

Non-classical form of congenital adrenal hyperplasia in patients with bilateral incidentalomas – hormonal and genetic analysis

Przybylik-Mazurek Elwira , Kurzynska Anna , Skalniak Anna , Hubalewska-Dydejczyk Alicja

Incidentalomas of adrenal glands are found in approximately 0.4–4.4% of abdominal CT-scan examinations and some of them can be caused by congenital adrenal hyperplasia (CAH). Bilateral masses can be detected in 10–15% of cases. CAH is one of the most common autosomal recessively inherited disorders. Non-classical form of congenital adrenal hyperplasia (NCCAH), is the milder form of the 21-hydroxylase deficiency, with the estimated incidence of 1:1000 worldwide.<p...

ea0056p69 | Adrenal cortex (to include Cushing's) | ECE2018

Adrenocortical carcinoma in the experience of one clinical center

Kurzynska Anna , Przybylik-Mazurek Elwira , Motyka Marcin , Hubalewska-Dydejczyk Alicja

Adrenocortical carcinoma (ACC) is a rare neoplasm with poor prognosis. Patients can present signs of hormone excess: virilisation, Cusging’s syndrome or only enlarged abdominal mass. Incidentally ACC can be also detected in the ultrasonography. Some of ‘non-hypersecretory’ ACCs can produce non-bioactive hormones steroid precursors or not very big amount of them and sometimes patients present subclinical Cushing’s symptoms. Surgery and adjuvant radiotherapy ...

ea0073pep9.2 | Presented ePosters 9: Endocrine-Related Cancer | ECE2021

Possible role of common RET polymorphisms in pheochromocytoma

Skalniak Anna , Rzepka Ewelina , Przybylik-Mazurek Elwira , Hubalewska-Dydejczyk Alicja

BackgroundIn about 2/3 of pheochromocytoma patients, no pathogenic germline variant can be identified that might be responsible for the onset of the disease. However, in many patients, we observe the repeated appearance of one or more common polymorphisms in the gene RET. Each of them has been shown to be of no significance for pheochromocytoma and multiple endocrine neoplasm type 2 development, when analysed individually. We decided to test whe...

ea0063p1055 | Pituitary and Neuroendocrinology 3 | ECE2019

Quality of life in patients with acromegaly assessed by AcroQoL- first application in South Poland

Przybylik-Mazurek Elwira , Krolak Monika , Joanna Marchlewska , Szlauer Anastazja , Hubalewska-Dydejczyk Alicja

Introduction: Acromegaly is a disease associated with increased secretion of growth hormone and subsequent growth of bones, soft tissues and internal organs. An important factor influencing therapeutic treatment in recent years is the patient’s quality of life associated with the disease. In patients with acromegaly, it is significantly affected by the occurrence of depression and anxiety - agents undergoing treatment, which, however, still appear undiagnosed.<p class...

ea0041ep39 | Adrenal cortex (to include Cushing's) | ECE2016

The classical form of congenital adrenal hyperplasia-clinical characteristics and genetic analysis

Przybylik-Mazurek Elwira , Kurzynska Anna , Skalniak Anna , Piatkowski Jakub , Hubalewska-Dydejczyk Alicja

Classical form of congenital adrenal hyperplasia (CAH) is associated with the impairment of enzymes involved in process of adrenal steroidogenesis. More than 90% of CAH cases are connected with mutations in the 21-hydroxylase gene CYP21A2 in the HLA class III area on the short arm of chromosome 6p21.3. CAH is characterized by a strong correlation between the genotype and the phenotype. Mutations in the CYP21A2 gene can cause different degrees of loss of 21-hy...

ea0041ep96 | Adrenal medulla | ECE2016

Usefulness of assessment of urinal metoxycatecholamines secretion in everyday clinical practice – pheochromocytoma as diagnostic challenge

Przybylik-Mazurek Elwira , Rzepka Ewelina , Buziak-Bereza Monika , Hubalewska-Dydejczyk Alicja

Introduction: Adrenal incidentaloma is an adrenal mass found on imaging studies done for other reason than suspected adrenal disease. The majority of them are non-functioning adenomas, however pheochromocytomas could be also observed. Currently, in diagnosis of incidentalomas, the assessment of hormones of adrenal cortex and medulla is performed. The aim of the study was to assess the incidence of pheochromocytoma in patients with incidentaloma.Methods: ...

ea0032p41 | Adrenal cortex | ECE2013

Non-classic adrenal hyperplasia (NCAH) in patients with bilateral adrenal incidentally discovered tumors

Przybylik-Mazurek Elwira , Tracz-Bujnowicz Marta , Kuzniarz-Rymarz Sylwia , Hubalewska-Dydejczyk Alicja

The prevalence of adrenal incidentalomas in computed tomography (CT) studies ranges from 0.6–1.9%. Adrenal masses are detected bilaterally in 10–15% of the cases.Non-classic adrenal hyperplasia (NCAH), also termed as late onset of CAH, is a very mild form of 21-hydroxylase deficiency. The incidence of disease is estimated at 0.1% of population. Reported prevalence in women with androgen excess range from 0.6 to 9%.Some pa...

ea0016p317 | Endocrine tumours | ECE2008

The prognostic factors in adrenocortical carcinoma

Przybylik-Mazurek Elwira , Hubalewska-Dydejczyk Alicja , Kuzniarz Sylwia , Lubaszewska Katarzyna , Huszno Bohdan

Adrenocortical carcinoma (ACC) is a rare neoplasm with poor prognosis. Patients present signs of hormone excess: virilisation, Cushing’s syndrome or only enlarged abdominal mass. Incidentally ACC can be also detected in the ultrasonography. Some of ‘non-hypersecretory’ ACCs can produce non-bioactive hormones steroid precursors or not very big amount of them and sometimes patients present subclinical Cushing’s symptoms. Surgery and adjuvant radiotherapy and ...

ea0041ep280 | Clinical case reports - Pituitary/Adrenal | ECE2016

Pheochromocytoma – the rare reason of Cushing’s syndrome due to ectopic corticotropin secretion

Przybylik-Mazurek Elwira , Rzepka Ewelina , Kurzynska Anna , Hubalewska-Dydejczyk Alicja , Sowa-Staszczak Anna , Budzynski Andrzej , Bialas Magdalena , Chrzan Robert

Cushing syndrome due to ectopic (adrenocorticotropic hormone) ACTH secretion (EAS) constitutes approximately 10% of Cushing’s syndrome (CS). In this group only in about 5% cases pheochromocytoma is the source of ACTH.We present two patients with EAS by pheochromocytoma.1. A 70 year-old woman with 3-months history of malaise, weakness, abdominal pain, loss of weight and appetite, hypertension and diabetes mellitus. One month ea...