Endocrine Abstracts

Introduction: Spontaneous hypoglycemia in non-diabetic patients is a rare metabolic emergency caused by multiple etiologies. Factitious hypoglycemia, a form of the Munchausen syndrome, is defined as the surreptitious use of insulin or oral hypoglycemic agents to deliberately induce self-harm. It is one of the most challenging diagnoses associated with significant morbidity and mortality. The aim of this study was to assess the prevalence and the associated factors of factitiou...

Introduction: Hypothyroidism is a very common condition, and its treatment is relatively easy with levothyroxine (LT4). However, cases of resistant hypothyroidism were reported despite high doses of levothyroxine. The aim of this study was to evaluate the usefulness of the levothyroxine absorption test to confirm or exclude a disorder of thyroid hormone absorption.Methods: This was a retrospective study including patients who were admitted to our departm...

Introduction: Acromegaly is a rare endocrine disorder. In 95% of cases, it is caused by a GH-secreting pituitary adenoma. Rarely, acromegaly is due to ectopic production of GH or growth hormone-releasing hormone (GHRH). Herein, we report a case of acromegaly with negative pituitary magnetic resonance imaging (MRI) and discuss its possible etiology and management.Observation: A 75-year-old woman was referred to our department for the exploration of acquir...

IntroductionAcromegaly is an endocrine disorder resulting from an excess of growth hormone (GH). The cause is almost always a pituitary adenoma, and it affects through the insulin-like Growth Factor 1 (IGF-1) the cellular proliferation, increasing therefore the risk of malignancy. Herein, we describe a case of coexistence of papillary thyroid carcinoma and primary hyperparathyroidism in a patient with acromegaly.Case report<p c...

Introduction: Primary hyperparathyroidism is the most common manifestation of multiple endocrine neoplasia (MEN) type 1, with a frequent involvement of all the parathyroids. In cases where the four glands weren’t resected, a close monitoring should be performed for an early diagnosis of recurrence. Elevated calcium levels with elevated parathormone (PTH) levels in this context makes the physician suspect an adenoma or a hyperplasia of the remaining parathyroid. We herein ...

Introduction: Metformin is the first-line treatment of type 2 diabetes mellitus. Poor adherence can be lead to poor glycemic control. The aim of our study was to determine the level of metformin adherence and its link with glycemic control in type 2 diabetic patients.Methods: We performed a cross-sectional study including 273 patients with type 2 diabetes taking metformin for at least three years. We assessed metformin adherence using the Girerd question...

Introduction: Pituitary adenomas represent 10 to 20% of intracranial tumors. In children, craniopharyngioma are the most common tumor of the sellar region. The symptoms can include headache, vomiting, pituitary deficiency and in pituitary adenomas, hormonal excess. The visual examination can find a visual field defect such as a bitemporal hemianopsia. We present a rare case of a pituitary adenoma in a 15-year-old girl with binasal hemianopsia.Observation...

Introduction: Kallmann syndrome is a rare genetic condition characterized by the association of a hypogonadotropic hypogonadism and anosmia. It results from the failure of GnRH cells to migrate to the hypothalamus and lack of development of the olfactory bulb. The main symptom of Kallmann syndrome is delayed or incomplete puberty usually associated with an impaired sense of smell. We herein describe a case of Kallmann syndrome discovered at the age of 57 years old.<p class...

Introduction: Most brand-name drugs do not differ that much from their generic counterparts, so switching between the two is not an issue. Levothyroxine, however, is an exception. The question of generic equivalency of levothyroxine products has remained unanswered for several decades. The purpose of the present study was to learn whether there is a difference of dosage between brand-name and generic levothyroxine in patient with well controlled primary hypothyroidism<p cl...

Introduction: Treatment of primary hypothyroidism relies on a daily intake of levothyroxine, which dosage is determined first by the weight then by TSH levels monitoring. The daily dosage can vary with the cause of the hypothyroidism and the weight. The aim of our study was to determine if the adherence was a factor influencing the dosage of levothyroxine in a group of well-controlled hypothyroid patients.Method: We performed a cross-sectional study incl...