Endocrine Abstracts

Introduction: Familial Adenomatous Polyposis (FAP) is an autosomal dominant disease classically characterized by the development of hundreds or thousands of adenomas in the rectum and colon during the second decade of life. Almost all patients will develop colorectal cancer (CRC) if not identified and treated at an early stage. It is a multisystem growth disorder so there is an increased risk of developing extraintestinal manifestations. In this context, an increase in adrenal...

Introduction: Familial Adenomatous Polyposis (FAP) syndrome is an autosomal dominant disorder associated with a high risk of multiple intestinal and extraintestinal cancers. They develop hundreds or thousands of adenomas in the rectum and colon during the second decade of life that. If they are not identified and treated, almost all patients develop colorectal cancer (CRC) and die by the age of 40-50 years. Thyroid carcinoma is a FAP manifestation with an unknown reported high...

Introduction: Adequate iodine intake is important in pregnant women.Objective: To determinate iodine status and thyroid volumen (TV) in healthy pregnant women from Navarra (Spain), and to evaluate possible influence of diet.Methods: A cross-sectional study of 144 women in the first trimester of pregnancy (single pregnancies) was carried during 2014. We measured thyroid-stimulating hormone (TSH), free thyroxine (fT4) and antithyroid...

Objective: Immune checkpoint inhibitors (ICPI) have become an effective therapeutic option for certain advanced malignant tumours. Immune-related adverse events affecting thyroid function are among the most frequent toxicities. The aim of our study is to determine the prevalence of thyroid disorders in patients undergoing treatment with ICPI.Methods: Retrospective study including all patients treated with ICPI in our centre, from 07/2015 to 12/2017. Pati...

Serum thyroglobulin (Tg) is a biomarker used to assess iodine nutrition status, but data in pregnant women are scarce.Objectives: To determine serum Tg concentration in Spanish healthy pregnant women, and to evaluate its relation with yoduria (UIC), thyroid volume, iodine intake and thyroid function throughout pregnancy.Methods: Longitudinal study in pregnant women with no history of thyroid disease, recruited in 2 obstetric center...

Evidence on whether neonatal thyroid screening results are dependent on maternal thyroid function is limited.Objectives: To study the relationship between iodine status and maternal thyroid function in pregnancy, and neonatal screening results in a Northern Spanish population.Methods: Prospective, longitudinal study of 297 pregnant women recruited in 2 obstetric centers of Pamplona (Spain) at the first antenatal visit, and their ne...

Bariatric surgery (BS) improves quality of life and health due to the beneficial effect on the metabolism at multiple levels. Specifically, its effectiveness in weight loss and the attenuation or resolution of comorbidities associated with obesity, means lower morbidity and mortality compared to other types of interventions. The objective is to analyze the evolution of obesity-related diseases after twelve months of follow-up.Methods: Retrospective study...

Background: The main limitation of fine-needle aspiration (FNA) is represented by indeterminate category (Bethesda III and IV) in which the risk of malignancy is between 5-30%. Given this result, surgical treatment is necessary in many cases. The aim of our study is to assess whether the ultrasound patterns proposed by the ATA, help us to stratify the risk of malignancy in nodules with Bethesda IV cytology result.Methods: From January 2011 to June 2017 w...

Objetive: The aim of our study is to asses the validity of ultrasound patterns proposed by the ATA and malignancy risk in the cytological diagnosis classified by the Bethesda System.Methods: Prospective study including all thyroid nodules (with no previous cytological results), assessed in our center from July/2016 to June/2017. We classified nodules in ATA sonographic risk patterns and follow-up its fine needle aspiration (FNA) recommendations. The stat...

Introduction: Lingual thyroid ectopia is a rare congenital abnormality affecting embryogenesis of the gland descent from foregut through pre-tracheal region in the neck. Most cases have an asymptomatic course but may occasionally produce local obstructive symptoms. Diagnostic methods are 99mTc, 131I or 123I radionuclide scan, computed tomography scan, magnetic resonance, and ultrasound. Surgery is the elective treatment for cases presenting com...