ea0021p240 | Neuroendocrinology and behaviour | SFEBES2009
Livingstone Dawn
, Chenjing Yang
, Emma Di Rollo
, Madina Kara
, John Mathews
, Lucy Codrington
, Christopher Kenyon
, Brian Walker
, Ruth Andrew
5alpha-Reductase1 (5aR1) catalyses glucocorticoid metabolism, potentially modulating glucocorticoid clearance and therefore affecting the activity of the hypothalamicpituitaryadrenal (HPA) axis. 5aR1 is up regulated in obesity associated with activation of the hypothalamicpituitaryadrenal (HPA) axis. Here we investigated if inhibition of 5aR1 impairs glucocorticoid clearance and suppresses the HPA axis.Age-matched male and female ...