Searchable abstracts of presentations at key conferences in endocrinology

ea0065p107 | Bone and calcium | SFEBES2019

Not all cases of hypercalcemia with calcium above 3.0 mmol/l and raised parathyroid hormone levels are due to primary hyperparathyroidism

Francis-Emmanuel Patrice , Tauni Rahat

Parathyroid hormone-dependent hypercalcaemia is one of the commonest conditions seen in endocrinology clinics. Primary hyperparathyroidism (PHPT) is the usual cause although some cases are due to other conditions including familial hypocalciuric hypercalcaemia (FHH). Making the distinction between PHPT and FHH is important in order to avoid unnecessary parathyroid surgery. Urinary calcium quantification is an integral part of diagnostic investigations. We present the case of a...

ea0067gp38 | Poster Presentations | EYES2019

Management of (severe) primary hyperparathyroidism in pregnancy

Tauni Rahat , Francis-Emmanuel Patrice

: Primary hyperparathyroidism (PHPT) is a common endocrine condition but is relatively rare in very young people and during pregnancy. The diagnosis in pregnancy poses a unique challenge and is often missed as the symptoms of hypercalcemia mimic those in pregnancy. We present the case of a 20-year old woman who was found to have severe hypercalcemia after she had persistent vomiting in early pregnancy. Biochemistry revealed adjusted calcium of 5.34 mmol/L, parathormone of 103....

ea0090p807 | Late-Breaking | ECE2023

Retinal quantitative traits as prognostic factors for diabetic cardiomyopathy in people with type 2 diabetes: A scoping review

Sandoval Garcia Emmanuel , Stephani Hellwege Rubi

Introduction: Heart failure (HF) morbidity and mortality are increasing at an alarming rate in people with type 2 diabetes (T2D). Myocardial dysfunction may develop without ischemic heart disease (IHD), hypertension, or valvular pathologies, and which is defined as diabetic cardiomyopathy (DCM). Although the pathophysiology of DCM is unclear, DCM is initially characterised by myocardial fibrosis, dysfunctional remodelling, and associated diastolic dysfunction, later by systoli...

ea0065p103 | Bone and calcium | SFEBES2019

A case of severe hypercalcemia detected in early pregnancy

Francis-Emmanuel Patrice , Wijenaike Nishan , Tauni Rahat

Primary hyperparathyroidism (PHPT) is a common endocrine condition. Outside of syndromic presentations, it is relatively rare in young people and during pregnancy. The diagnosis in pregnancy poses a unique challenge and is often missed as the symptoms of hypercalcemia mimic those in pregnancy. We present a case of a 20-year old woman who was found to have severe hypercalcemia after she had persistent vomiting in early pregnancy. Biochemistry showed adjusted calcium of 5.34 mmo...

ea0035p1042 | Thyroid (non-cancer) | ECE2014

Antithyroid drug-induced agranulocytosis: experience of the French centers of Pharmacovigilance with a retrospective study of more than 200 cases

Andres Emmanuel , Weitten Thierry , Alt-Tebacher Martine

Objective: Agranulocytosis to the antithyroid drugs is a rare adverse drug effect exposure to potentially lethal infections. It is a public health problem with hyperthyroidism in nearly 1% of the French population. However, many uncertainties remain in the knowledge, understanding, prevention and management of this drug effect. In this work, we report the French experience through pharmacovigilance data.Materials and methods: This is a retrospective stud...

ea0091p3 | Poster Presentations | SFEEU2023

A rare case of hypergonadotropic hypogonadism: A combination of two rare entities

Ssemmondo Emmanuel , Sathyapalan Thozhukat , Aye Mo , Mongolu Shiva , Deshmukh Harshal

Case History: This 19-year-old Caucasian female was seen in the Endocrine clinic with history of primary amenorrhea. She had a low sexual drive, no breast development but reported presence of axillary and pubic hair growth. Her main concern was whether she would be able to conceive. She had no comorbidities and took no regular medications. She never smoked and consumed no alcohol. On examination, she was 171 cm tall with a weight of 65.5 kg. She had normal external female geni...

ea0069p38 | Poster Presentations | SFENCC2020

Requirement of staged interventions in a complex case of Acromegaly and Obstructive Sleep Apnoea

Dhar Mili , Elias Jennifer , Field Benjamin , Zachariah Sunil , Emmanuel Julian

Section 1: Case history: We present the case of a 35-year-old gentleman referred by his GP to Endocrinology clinic for loss of libido and testosterone deficiency. His co-morbidities included obesity (BMI 59 kg/m2), hypertension and obstructive sleep apnoea (OSA) requiring overnight continuous positive airways pressure (CPAP) therapy. Routine pituitary profile showed luteinising hormone 4.8 IU/l (1–8), testosterone 7.1 nmol/l (8–25), prolactin 232 mU/l (86&...

ea0059p051 | Bone and calcium | SFEBES2018

Chromolaena odorata and Tithonia diversifolia synergistically stimulate kidney erythropoietin and repress cyclin-dependent kinase inhibitors in the bone marrow of Wistar rats

Omotuyi Olaposi , Nash Oyekanmi , Ukwenya Victor , Gbadamosi Emmanuel

Aim: Chromolaena odorata and Tithonia diversifolia have been combined as folkloric treatment for pediatric anemia. However, the underlying molecular mechanism of this pharmacology has not been established. This study sought to establish the effects of these plants on erythropoietin (kidney), and erythropoietin receptor (bone marrow) expression and to monitor cyclin-dependent kinase inhibitors, and FasL/FAS signaling mechanism therefrom....

ea0037ep833 | Thyroid cancer | ECE2015

Sarcoidosis in a 53-year-old women followed for a refractory thyroid carcinoma: a misleading association

Thuillier Philippe , Roudaut Nathalie , Kerlan Veronique , Emmanuel Sonnet

Sarcoïdosis is a relatively frequent systemic disease of unknown origin. Prevalence is about 4.7–64 in 100 000. We report the case of a 53-year-old woman followed in our institution since 2007 for a thyroid carcinoma. In 2010, she was diagnosed refractory thyroid carcinoma because of a high thyroglobulin assay (477 μg/l) without uptake on post-therapeutic (131I) whole body scan. Thereafter, the story is marked by the appearance in 2011 of multiple cer...

ea0025p297 | Steroids | SFEBES2011

Effects of endocrine disruptors in adult rats: integrative evaluation from gonadal steroidogenic gene expression profiles to hormonal balance

Quignot Nadia , Desmots Sophie , Barouki Robert , Lemazurier Emmanuel

Endocrine disruptors are chemicals that can alter functions of the endocrine system by several ways. Their risk assessment with regard to REACH legislation remains a challenge. In the present study, we propose an integrative evaluation for the effects of some endocrine disruptors on hormonal balance in male and female adult rats. We focused our work on the last step of steroidogenesis, where two enzymes are implicated: aromatase, which plays a central role by catalyzing the ir...