Endocrine Abstracts

Background: Nowadays, primary hyperparathyroidism is usually diagnosed incidentally, in asymptomatic patients, while only around 15% of patients present the classical manifestations. Osteoclastoma, a benign bone lesion, is usually the late manifestation of hyperparathyroidism.Objective: We present the case of a 52 years old female (non-menopausal) recently diagnosed with ulnar osteoclastoma, primary hyperparathyroidism and secondary osteoporosis.<p c...

Introduction: Cushing disease is the most common cause of endogenous hypercortisolemia and most frequently is caused by microadenomas, but rarely, only in 10% to 20% of cases, the adenomas are large enough to produce mass effect.1Case report: We present the case of a 63 years old female patient, diagnosed in 2007 with a 22/18 mm non-secreting pituitary adenoma and panhypopituitarism. She undergone transsphenoidal surgery twice, followed by gam...

Background: The role of inflammation in the pathogenesis of cancer and the mechanisms through which platelets can influence the aggressive behaviour of different types of cancer have been highlighted by a few studies.Methods: We retrospectively analysed the files of 493 patients submitted to thyroidectomy in our surgery department between 2012 and 2015. We assessed the relationship between differentiated thyroid cancer (DTC) and mean platelet volume (MPV...

Introduction: Although calcifications are a relatively common finding on a thyroid ultrasound, present in both benign and malign lesions, osseous metaplasia (OM) is a peculiar discovery, with only a few described cases in literature so far. Common pathophysiological explanations include abnormalities of bone morphogenetic protein family members and basic fibroblast growth factor. Most of the case reports are presenting OM in association with malign lesions, often with papillar...

Introduction: Glucagonoma is a rare pancreatic neuroendocrine functional tumor, with an estimated incidence of 1 in 20 million people. At the moment of diagnosis, the majority of patients present locoregional and liver metastases.Case report: We present the case of a 46 years old male patient, diagnosed with glucagon secreting pancreatic neuroendocrine tumor in February 2018. As part of the glucagonoma syndrome, the patient was also suffering from insuli...

Objectives: In recent studies, neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) are being investigated as prognostic and diagnostic markers for many malignancies, including thyroid cancer. The aim of our study was to investigate if a relationship exists between NLR and PLR and thyroid cancer.Materials and methods: We retrospectively analysed the files of 953 patients who underwent thyroidectomy in our surgery department between...

Objectives: In the last decades, thyroid cancer incidence has increased all over the world. This may be due to heightened medical surveillance and more addressability to surgery, as many cancers are diagnosed while under 1 cm. The aim of our study was to obtain data about the prevalence and histological subtypes of primary thyroid carcinoma in patients undergoing thyroidectomy.Materials and methods: We retrospectively analysed the files of 953 patients w...

In 2022, the 5-year prevalence of thyroid cancer in Romania was 2.1/100.000. Differentiated thyroid cancer (DTC), the predominant form, often necessitates surgery and TSH suppressive therapy (TST). If severe and prolonged, this may accelerate bone remodelling, resulting in osteoporosis and increased fracture risk. This retrospective study aimed to assess the impact of TST on bone metabolism in a cohort of DTC patients. We analyzed: age, menopausal status, degr...