ea0065ec1.2 | Early Career Prize Lecture Translational | SFEBES2019
Ajjan Ramzi
, Hensor Elizabeth
, Abbas Afroze
, Galdo Francesco Del
, Russell David
, Shams Kave
, Stewart Paul
, Webber Lorraine
, Pegg Lindsey
, Freeman Adrian
, Woods Janet
, Eng Sookhoe
, Taylor Angela
, Arlt Wiebke
, Tahrani Abd
, Tiganescu Ana
The International Diabetes Federation estimates that type 2 diabetes mellitus (T2DM) will affect 642 million people by 2040. Chronically inflamed, hypoxic wounds are common in T2DM and represent a global unmet clinical need. Each year, diabetic foot ulcers cost the NHS £650 million and cause 1 in 200 UK deaths. This mortality is greater than colon, breast and prostate cancer combined. Glucocorticoids are used to treat a range of inflammatory conditions (e.g. asthma, eczem...