Searchable abstracts of presentations at key conferences in endocrinology

ea0086p42 | Endocrine Cancer and Late Effects | SFEBES2022

Hydroxymethylation is dysregulated in pancreatic neuroendocrine tumours and associated with aberrant DNA methylation

English Katherine A , Selberherr Andreas , Shariq Omair A , O'Neill Eric , Lines Kate W , Thakker Rajesh V

Pancreatic neuroendocrine tumours (PNETs) have a lower mutational burden than other tumours, indicating that other mechanisms contribute to tumourigenesis. One such reported mechanism is DNA methylome dysregulation, however, inconsistencies have been observed between gene methylation and protein expression, potentially stemming from the use of standard methylation assessment methods which do not distinguish methylation (5’methylcytosine (5’mC), repressive mark) from ...

ea0065p275 | Neuroendocrinology | SFEBES2019

Predictive power of ACTH and cortisol in the early post-operative period following pituitary surgery: relationship to long term glucocorticoid requirement

English Katherine , Chikani Viral , Jang Christina , Dimeski Goce , Olson Sarah , Inder Warrick

Hypothalamic–pituitary–adrenal (HPA) axis function after trans-sphenoidal pituitary surgery is commonly assessed using post-operative morning cortisol. We performed a prospective study to determine the sensitivity and specificity of cortisol and ACTH measured within the first 24 h, in predicting glucocorticoid requirement at 6 months both in patients with pre-operative secondary adrenal insufficiency (SAI) and with normal pituitary function. Exclusion criteria includ...

ea0065p280 | Neuroendocrinology | SFEBES2019

Prognostic indicators of metastatic neuroendocrine tumour of unknown primary site: a single centre retrospective study

English Katherine , Healy Ultan , Tadman Michael , Thakker Rajesh V , Talbot Denis , Abeyaratne Dayakshi , Silva Michael , Soonawalla Zahir , Fryer Eve , Shine Brian , Grossman Ashley B , Pal Aparna , May Christine , Weaver Andrew , Jafar-Mohammadi Bahram

Neuroendocrine tumours (NETs) presenting as metastatic cancer of unknown primary site (CUP) are suspected to confer poorer prognosis compared to metastatic NETs of known primary site. We performed a retrospective, single centre study to determine the prognostic indicators in CUP-NETs compared to metastatic small intestinal NET (SiNET), before and after adjusting for factors known to affect overall survival. Subjects were selected from a departmental database of 1050 NET patien...