Endocrine Abstracts

Prostate cancer (PCa) is one of the leading causes of cancer deaths among men population worldwide. This tumour pathology is commonly diagnosed through the determination of serum PSA levels. However, the diagnostic capability of PSA dramatically drops when considering patients with PSA levels lower than 10 ng/ml, the so-called “grey-zone”1. Therefore, additional non-invasive diagnostic biomarkers are urgently needed to substitute/complement PSA. In this se...

Somatostatin (SST), Cortistatin (CORT), Neuronostatin (NST) and their receptors [SST/CORT-receptors (sst1–5/sst5TMD4-TMD5) and NST-receptor (GPR107)] comprise a hormonal pleiotropic system involved in the regulation of multiple pathophysiological functions. Certain components of this system are dysregulated in endocrine-related cancers, including prostate cancer (PCa), wherein we have found that alterations in specific components of this regulatory system [i.e. NST-GPR10...

Prostate cancer (PCa) is one of the most common causes of cancer-related deaths in men worldwide. Therefore, more specific and non-invasive diagnostic biomarkers as well as novel therapeutic targets are urgently needed. As miRNAs have been proposed as promising elements for the identification of novel diagnostic and therapeutic tools for different pathologies, including cancer, we investigated the miRNA landscape in PCa and explored their putative diagnostic/therapeutic utilit...

IntroductionAlternative splicing allows the generation of multiple RNA isoforms from a single pre-RNA molecule, and thereby contributes to a multitude of physiological processes, but can also be involved in many diseases, including cancer. Indeed, disruption of alternative splicing has been linked to key cancer features, such as tumor growth, metastasis and hormone responsiveness and is increasingly regarded as a novel and transversal cancer hallmark. Th...

Prostate cancer (PCa) is the second most diagnosed cancer type and the sixth cause of cancer death among men worldwide. Due to the usual slow course of the progression of this disease, there is a growing interest in finding chemopreventive therapeutics with a low risk of side effects. In line with this, recent studies have shown that hydroxytyrosol (HT), one of the main extra virgin olive oil phenolic compounds, exerts a protective role against different cancer types. Moreover...