Searchable abstracts of presentations at key conferences in endocrinology

ea0032p900 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Increased thyroid cancer risk in acromegaly

Dagdelen Selcuk , Cinar Nese , Erbas Tomris

Introduction: Generously supported by IPSEN)-->Acromegaly increases cancer risk. We aimed to determine the prevalence and the predictors of tumors in acromegalic patients treated at our department.Design: We retrospectively evaluated 142 acromegalic patients (75 females (mean age 52.1±10.4 years and 67 males (mean age 49.4±12.7 years)) treated at university center, endocrinology outpatient clinic betw...

ea0056p235 | Calcium &amp; Vitamin D metabolism | ECE2018

Maximal foot force and plantar pressure distribution assessed by Footscan is not affected in asymptomatic primary hyperparathyroidism patients

Oguz Seda , Unluturk Ugur , Nahit Sendur Suleyman , Erbas Tomris

Background: Primary hyperparathyroidism (PHPT) is associated with various musculoskeletal complaints. It is difficult to evaluate muscle strength as it is hard to extract objective data due to lack of definite methods for measurement.Objective: To assess the differences between PHPT patients and healthy controls regarding maximum foot force and plantar pressure distribution by using platform pressure measuring system [Footscan (RSscan)].<p class="abs...

ea0081p100 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The trigliserid-glucose index shows a stronger correlation with serum adiponectin levels than HOMA-IR

Nahit Sendur Suleyman , Isgin Atici Kubra , Turan Demirci Busra , Lay Incilay , Buyuktuncer Zehra , Erbas Tomris

Objective: Different methods are used to identify individuals with insulin resistance. The gold standard is the euglycemic-hyperinsulinemic clamp. However, in clinical practice, clamp is not preferred because it is cumbersome, the HOMA-IR index is used more often. The Trigliserid-glucose (TyG) index is a new and practical way to identify individuals with insulin resistance (IR). When compared to HOMA-IR, this index has been shown to be more reliable in determining insulin resi...

ea0041gp67 | Clinical Case Reports | ECE2016

Nivolumab associated thyroiditis in a patient with squamous non small cell lung cancer

Sendur Ayse , Sendur Suleyman Nahit , Demirkazik Ahmet , Dagdelen Selcuk , Erbas Tomris

Nivolumab is the first programmed death 1 (PD-1) immune checkpoint inhibitor. It is approved for use in advanced melanoma and squamous non small cell lung cancer (NSCLC). PD-1 immune checkpoint inhibitors can cause autoimmune disease of endocrine glands, including the thyroid. Here, we present a case of thyroiditis after nivolumab therapy.A 61 year-old female patient with NSCLC was consulted to endocrinology department for abnormal thyroid function test ...

ea0035p48 | Adrenal cortex | ECE2014

Retrospective analysis of adrenal ıncidentalomas: a single center experience

Akin Safak , Helvaci Nafiye , Dagdelen Selcuk , Yildiz Bulent Okan , Gurlek Alper , Erbas Tomris , Bayraktar Miyase

Background and aim: Incidentally discovered adrenal masses (adrenal incidentalomas (AI)), generally 1 cm or more in diameter, are mostly benign and asymptomatic and are often considered as nonfunctional tumors. The aim of this study was to perform the imaging characteristics, endocrinologic screening and histologic diagnoses of adrenal incidentaloma cases encountered in our institute.Methods: This retrospective evaluation of patients with AI includes 543...

ea0035p388 | Diabetes (epidemiology, pathophysiology) | ECE2014

What is the contribution of MODY gene polymorphisms in the development of gestational diabetes mellitus?

Cikman Duygu Ilke , Cikman Muzaffer Seyhan , Erbas Tomris , Alikasifoglu Mehmet , Dagdelen Selcuk

Objective: Gestational diabetes mellitus (GDM) is the consequence of increased insulin resistance during pregnancy in predisposed individuals who already have impaired insulin secretion due to beta-cell dysfunction as in maturity onset diabetes of young (MODY) cases. Here we aimed to document the association between MODY subtypes and GDM to understand the pathogenesis of GD.Design: Matched, case-control study.Method: Ninety-three p...

ea0070aep768 | Pituitary and Neuroendocrinology | ECE2020

A case of isolated ACTH deficiency and autoimmune pancreatitis associated with pembrolizumab treatment

Unluturk Uğur , Hanife Oguz Seda , Aksoy Sercan , Erbas Tomris

Background: Endocrine-related adverse effects of immune check-point inhibitors (ICIs) have been identified in growing number of cancer patients.Case presentation: A 49-year-old male with laryngeal cancer applied to ouroutpatient clinic with weakness, loss of appetite, weight loss, nausea and vomiting for the last three weeks. He was diagnosed with T3N1M0 laryngeal squamous cell cancer seven months before this admission and was given concurrent cisplatin ...

ea0070aep1011 | Hot topics (including COVID-19) | ECE2020

A case of posaconazole associated adrenal insufficiency developing in the course of acute myeloid leukemia

Fevzi Degirmenciler Ridvan , Metan Gokhan , Ozcebe Osman , Gonul Iremli Burcin , Erbas Tomris

Posaconazole is a member of triazole antifungal family. It is frequently used prophylaxis and treatment in invasive fungal infections. Among the azole group antifungals, ketoconazole is well known to affect steroidogenesis through cytochrome P450 enzymes, however, posaconazole-induced adrenal insufficiency has been reported in only two cases in the literature. Here, we present our case of adrenal insufficiency induced by posaconazole.A 54-year-old male a...

ea0070aep1072 | Hot topics (including COVID-19) | ECE2020

Pregnancy outcomes in acromegaly: A single tertiary center case series

Gonul Iremli Burcin , Hanife Oguz Seda , Firlatan Busra , Dagdelen Selcuk , Erbas Tomris

Introduction: Pregnancy occurs relatively rare women with acromegaly. However, in recent years, pregnancy has become more likely to occur in acromegalic women possibly due to improvements in acromegaly treatment, and advanced assisted reproduction techniques.Methods: In this case series, we retrospectively analyzed 11 pregnancies of 8 acromegalic women followed in the university hospital in a time range between 2009–2019. Data were obtained from pa...

ea0032p62 | Adrenal cortex | ECE2013

Metastatic adrenocortical carcinoma presenting with concomitant secretion of glucocorticoid, mineralocorticoid, androgen, and catecholamines: a case report

Akin Safak , Dagdelen Selcuk , Yuksel Elif , Altindag Kadri , Sayek Iskender , Baydar Dilek Ertoy , Erbas Tomris

Introduction: We report the first case of metastatic adrenocortical carcinoma (ACC) concomitantly secreting cortisol, aldosterone, catecholamines and androgens with the extensive distant metastasis at the time of diagnosis.Case report: A 57-year-old woman referred for left adrenal mass (5.5×4.0 cm) two years after the diagnosis of breast cancer. The patient’s medical history revealed hypertension and diabetes mellitus. She has cushingoid and hy...