Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep704 | Pituitary and Neuroendocrinology | ECE2022

Cessation of GH secretion in acromegaly without medical or surgical intervetion; Covid-postponed surgery was escaped

Erdei Annamaria , Daniel Eszter , Gazdag Annamaria , Griger Miha ly , Nagy Edit B , Nagy Endre V

Introduction: Acromegaly is usually caused by pituitary macroadenoma producing excess growth hormone. Treatment options include surgery to remove the tumor, medications, and radiation therapy.Case report: A 39-year-old woman has been referred to the endocrine clinic with suspected acromegaly in December 2019. Surgery for benign ovarian cyst, endometriosis, amenorrhoea, unsuccessful in vitro fertilisations were present in her medical history. She complain...

ea0014p354 | (1) | ECE2007

Endothelial function and hemostasis factors in hypothyroidism and subclinical hyperthyroidism

Gazdag Annamaria , Nagy V Endre , Varga Emma , Samson Laszlo , Erdei Annamaria , Jenei Zoltan

Long-term follow-up of differentiated thyroid cancer (DTC) patients requires yearly measurements of serum thyroglobulin (Tg) levels is endogenous (4 weeks off-thyroxin) or exogenous (human recombinant TSH injection) high TSH state. Subclinical hyperthyroidism is maintained in the patients throughout the rest of the year. We examined the endothelial function, hemostasis factors and metabolic parameters in short-term iatrogenic hypothyroidism (HO) and in subclinical hyperthyroid...

ea0014p358 | (1) | ECE2007

Water purification technology reduces iodine content of drinking water and contributes to iodine deficiency

Samson Laszlo , Czegeny Ildiko , Nagy Endre V , Mezosi Emese , Erdei Annamaria

Drinking water is the major natural source of iodine in many European countries. In the present study, we examined possible sites of iodine loss during the usual water purification process. Water samples from 6 sites during the technological process were taken and analyzed for iodine content. Under laboratory circumstances, prepared iodine in water solution has been used as a model to test the effect of the presence of chlorine. Samples from the purification sites revealed tha...

ea0037gp.27.08 | Thyroid – hyperthyroidism and treatment | ECE2015

There is a detectable immune activity in the orbits of all patients diagnosed with Graves' disease regardless of later development of Graves' orbitopathy

Berta Eszter , Ujhelyi Bernadett , Szabados Lajos , Galuska Laszlo , Erdei Annamaria , Gazdag Annamaria , Halmi Sandor , Nagy Endre , Bodor Miklos

Graves’ orbitopathy (GO) is a common complication of Graves’ disease (GD) which is often responding poorly to therapy. GO may develop before or together with, or during the course of GD. In an individual patient, the development of GO cannot be predicted. We assumed that orbital autoimmune activity is predictable using orbital 99mTc-labelled diethylenetriamine pentaacetic acid (99mTc-DTPA) SPECT. We aimed to determine whether any orbital autoimmune activity can be id...

ea0084ps2-07-64 | Graves’ Disease 1 | ETA2022

The effect of glucocorticoids on hyaluronan production of orbital fibroblasts

Galgoczi Erika , Katko Monika , Erdei Annamaria , Bodor Miklos , Ujhelyi Bernadett , Steiber Zita , Gyory Ferenc , V. Nagy Endre

Objectives: Glucocorticoids (GCs) are the first line therapy in moderate to severe, active thyroid eye disease (TED). While their beneficial immunosuppressive effects are well known, direct connective tissue effects are less characterized. The accumulation of extracellular matrix component hyaluronan (HA) and increased proliferation rate of fibroblasts are hallmarks connective tissue changes in TED. We examined the effect of methylprednisolone (MP), prednisolone (P), hydrocort...

ea0056p126 | Endocrine tumours and neoplasia | ECE2018

Gastroenteropancreatic neuroendocrine tumors are predictive for a positive MEN1 germline mutation test: evidence from Hungarian MEN1 cohort

Kovesdi Annamaria , Balogh Katalin , Toth Miklos , Szucs Nikolette , Sarman Beatrix , Pusztai Peter , Reismann Peter , Somogyi Aniko , Borka Katalin , Erdei Annamaria , Deak Veronika , Valkusz Zsuzsanna , Igaz Peter , Patocs Attila , Grolmusz Vince Kornel

Objective: Multiple endocrine neoplasia type 1 (MEN1) is a rare heritable tumor syndrome caused by germline mutations of MEN1 gene affecting mainly the parathyroid, pituitary and pancreas. Phenotype varies widely, even in first-degree relatives. Recently it has been shown that functionally active gastroenteropancreatic neuroendocrine tumors (GEP-NETs), initially frequently diagnosed as sporadic cases, lead to MEN1 diagnosis. Non-functioning tumors are increasingly rec...