Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep1379 | Thyroid (non-cancer) | ECE2017

Effects of combination of metformin and pioglitazone on AMPK/mTOR signal pathway, p53 and apoptosis in human anaplastic thyroid cancer cells

Kutbay Nilufer Ozdemir , Erdogan Mehmet , Yurekli Banu Sarer , Kurt Cansu Caliskan , Gunduz Cumhur , Avci Cigir Biray

Thyroid cancer is the most common malignant tumor of the human endocrine system. Recently, its incidence has increased significantly. Anaplastic cancer constitutes 2–4% of thyroid cancers and remains aggressive. The life expectancy is 2–6 months. It is often beyond the surgical margin. External radiation therapy or chemotherapy are the treatment options. Therefore, new therapeutic approaches are needed. Peroxisome proliferator-activated receptor (PPAR) gamma is a DNA...

ea0035p73 | Bone and Osteoporosis | ECE2014

Efficacy of zoledronic acid treatment in Paget disease of bone

Baykan Emine Kartal , Saygili L Fusun , Erdogan Mehmet , Ozgen A Gokhan , Cetinkalp Sevki , Yilmaz Candeger

Purpose: Paget disease is a disease of bone of unknown etiology with increased bone turnover that results in defective bone microarchitecture and bone deformity. Bisphosphonates are used in symptomatic Paget disease of bone. Clinical trials have shown that zoledronic acid was more effective than other bisphosphonates in treatment of Paget disease.Methods: In this study, we retrospectively reviewed the remission and relapse statuses of 12 patients with Pa...

ea0035p521 | Endocrine tumours and neoplasia | ECE2014

A case of insulinoma localized in pancreas tail that cannot be monitored with endosonography and abdominal MR but with contrast abdominal BT

Kutbay Nilufer Ozdemir , Ocek Levent , Nart Deniz , Erdogan Mehmet , Cetinkalp Sevki , Ozgen A Gokhan , Saygili Fusun

Introduction: Insulinoma is a rare neuroendocrine tumor. 90% of insulinoma is solitaire and benign, and 10% is malignant. Although seen at any age, it is most commonly noticed in 4th and 6th decades.Case: A 78-year-old man was referred to a neurology clinic upon a sudden faint, disability to remember and meaningless behavior, and diagnosed with epilepsy in 2008. In 2012, he had a hypoglycemia attack (blood glucose 30 mg/dl) and was referred to Ege Univer...

ea0035p895 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

Six cases of FSH/LH positive pituitary adenomas

Kutbay Nilufer , Yurekli Banu Sarer , Erdogan Mehmet , Saygili Fusun , Ertan Yesim

Introduction: Immunocytochemistry methods have demonstrated that most of the ‘clinically non functional’ adenomas are actually gonadotrophin secreting adenomas or gonadotroph adenomas. Gonadotroph adenomas are discovered in patients presenting with visual field disorder. Pituitary imaging almost always demonastrates macroadenoma. Anterior pituitary insufficiency is much more frequent than gonad hyperstimulation. Herein, we present six cases of FSH and/or LH positive ...

ea0020p97 | Thyroid | ECE2009

Frequency of metabolic syndrome in hypothyroid patients

Ganidagli Sencer , Erdogan Mehmet , Kosenli Aybike , Kulaksizoglu Mustafa , Solmaz Soner , Sokmen Nebi , Canataroglu Abdullah

Objective: One of the common features of hypothyroidism is weight gain or failure to lose weight. Also bradycardia and mild hypertension can be seen. Impact of thyroid hormone deficiency on glucose and insulin metabolism is not fully understood. Thyroid hormones play role in lipid synthesis, metabolism and mobilization. Metabolic syndrome is a state which most features of hypothyroidism can be seen. Our aim is to investigate the frequency of metabolic syndrome in hypothyroid p...

ea0020p118 | Thyroid | ECE2009

Demographic, clinical, laboratory, ultrasonographic and cytological features of patients with Hashimoto’s thyroiditis: results of a university hospital of 769 patients in Turkey

Erdogan Mehmet , Erdem Nihat , Cetinkalp Sevki , Ozgen Gokhan , Saygili Fusun , Yilmaz Candeger , Tuzun Mehmet , Kabalak Taylan

Background: We investigated the demographic and clinical features of patients with Hashimoto’s thyroiditis who had been diagnosed and treated in Ege University, the main referral center in the Aegean region of Turkey.Methods: Medical records of patients who had been followed in the endocrinology clinic of Ege University were retrospectively evaluated. Patients who had been diagnosed as having any thyroid disorder were determined. Patients with Hashi...

ea0020p140 | Thyroid | ECE2009

Anemia frequency and etiology in primary hypothyroidism

Kosenli Aybike , Erdogan Mehmet , Ganidagli Sencer , Kulaksizoglu Mustafa , Solmaz Soner , Kosenli Ozgun , Unsal Cagatay , Canataroglu Abdullah

Objective: Thyroid hormones directly or indirectly, through erythropoietin, stimulate growth of erythroid colonies. Anemia is often the first sign of hypothyroidism. Hypothyroidism can lead to a wide variety (%20–60) of anemic disorders. Numerous mechanisms are involved in the pathogenesis of these anemias which can be microcytic, macrocytic and normocytic. Microcytic anemia is usually ascribed to malabsorption of iron and loss of iron by menorrhagia. Macrocytic anemia is...

ea0020p373 | Diabetes and Cardiovascular | ECE2009

Hyperhomocysteinemia may be a risk factor for diabetic foot ulcer development

Solmaz Soner , Erdogan Mehmet , Kulaksizoglu Mustafa , Ganidagli Sencer , Kosenli Aybike , Sakalli Hakan , Canataroglu Abdullah

Background: Diabetic foot ulcer and lower extremity amputation are leading causes of mortality and morbidity in diabetic patients. Diabetic neuropathy and peripheral vascular disease are major reasons for diabetic foot ulcer. Most of the studies showed that hyperhomocystinemia is related with microvascular and macrovascular complications in diabetic patients. Also hyperhomocysteinemia is related to poor ulcer healing. In this study, we investigated the relationship of hyperhom...

ea0020p387 | Diabetes and Cardiovascular | ECE2009

Plasma thrombin-activatable fibrinolysis inhibitor (TAFI) antigen levels in diabetic foot ulcers

Erdogan Mehmet , Solmaz Soner , Canataroglu Abdullah , Kulaksizoglu Mustafa , Cetinkalp Sevki , Ozgen Gokhan , Saygili Fusun , Yilmaz Candeger

Objective: Diabetic foot ulcer is associated with increased morbidity and mortality. The most important factor related to the development of foot ulcer is peripheral neuropathy. Thrombin-activatable fibrinolysis inhibitor (TAFI) is associated with coagulation, fibrinolysis and inflammation. Plasma TAFI may participate in arterial thrombosis in cardiovascular diseases (CVD). TAFI may be involved in the mechanism of vascular endothelial damage in diabetic patients. The aim of th...

ea0020p614 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Plasma thrombin-activatable fibrinolysis inhibitor antigen levels in acromegalic patients

Ozbek Mustafa , Erdogan Mehmet , Ceneli Ozcan , Saltas Hakan , Akbal Erdem , Kizilgun Mustafa , Ureten Kemal

Objective: Acromegaly is associated with increased morbidity and mortality, mostly due to cardiovascular complications. Thrombin-activatable fibrinolysis inhibitor (TAFI) is associated with coagulation/fibrinolysis and inflammation. Plasma TAFI may participate in arterial thrombosis in cardiovascular diseases (CVD). In this study, we aimed to evaluate the levels of TAFI antigen and also its relationship with other markers in a group of patients with acromegaly in compoa...