Searchable abstracts of presentations at key conferences in endocrinology

ea0042p10 | (1) | Androgens2016

Metastases-prone localized prostate cancer: a genomic analysis

Van den Broeck Thomas , Gevaert Thomas , Prekovic Stefan , Boeckx Bram , Smeets Elien , Ong Kaye , Lehrer Jonathan , Haddad Zaid , Erho Nicholas , Helsen Christine , Lambrechts Diether , Buerki Christine , Davicioni Elai , Joniau Steven , Claessens Frank

Clinical features of the primary prostate tumor remain insufficient for clinicians to accurately define patients at highest risk of developing metastases. However, the primary tumor is the source of these metastases, and thus should contain information on its metastatic potential. We hypothesized that the combination of a primary tumor’s copy number alterations (CNAs) and genome-wide transcriptome information would give us more insight in the biology of metastases-prone l...

ea0042oc9 | (1) | Androgens2016

Chromatin relaxation is a feature of advanced prostate cancer

Urbanucci Alfonso , Barfeld Stefan , Kytola Ville , Vodak Daniel , Sjoblom Liisa , Tolonen Teemu , Minner Sarah , Burdelski Christoph , Kivinummi Kati K. , Kregel Steven , Takhar Mandeep , Alshalalfa Mohammed , Davicioni Elai , Erho Nicholas , Karnes R. Jeffrey , Ross Ashley E. , Schaeffer Edward M. , Vander Griend Donald J. , Knapp Stefan , Tammela Teuvo L.J. , Sauter Guido , Schlomm Thorsten , Nykter Matti , Visakorpi Tapio , Mills Ian G.

Epigenetic reprogramming including altered transcription factor binding and altered patterns of chromatin and DNA modifications are now accepted as the hallmark of aggressive cancers. We show that global changes in chromatin structure and chromatin accessibility in prostate tumour tissue can define castrate-resistant prostate cancer and be used to inform the discovery of gene-level classifiers for therapy. In addition, we show that the androgen receptor overexpression alone, w...