Searchable abstracts of presentations at key conferences in endocrinology

ea0081rc12.2 | Rapid Communications 12: Reproductive and Developmental Endocrinology | ECE2022

Proteomic changes in response to electrical stimulations in skeletal muscle of women with PCOS

Eriksson Gustaw , Nilsson Emma , Boi Roberto , Nystrom Jenny , Stener-Victorin Elisabet , Benrick Anna

Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder affecting women of reproductive age. The main features of PCOS are hyperandrogenism and reproductive and metabolic dysfunctions. We have previously shown that muscle contractions induced by either electrical stimulations or exercise act through partially similar signaling pathways in the muscle to induce glucose uptake in the acute response. Long-term electrical stimulations decrease circulating testostero...

ea0081p195 | Reproductive and Developmental Endocrinology | ECE2022

The effect of dihydrotestosterone on the immune profile in a mouse model of Polycystic Ovary Syndrome

Torstensson Sara , Ascani Angelo , Lu Haojiang , Risal Sanjiv , Eriksson Gustaw , Li Congru , Benrick Anna , Obermayer-Pietsch Barbara , Stener-Victorin Elisabet

Polycystic Ovary Syndrome (PCOS) is an endocrine disorder affecting 10-15% of women worldwide, characterized by high androgen levels, anovulation and/or polycystic ovarian morphology. Chronic low-grade inflammation is associated with the disorder as well as many of its comorbidities, such as obesity and type-2 diabetes. To determine the role of the immune system in the pathophysiology of PCOS, we characterized the immune profile of the dihydrotestosterone (DHT)-induced PCOS-li...

ea0081ep871 | Reproductive and Developmental Endocrinology | ECE2022

Endometrial cell-type-specific disease signatures and endometrial organoids in polycystic ovary syndrome

Eriksson Gustaw , Li Congru , Pui Han-Pin , Risal Sanjiv , Hirschberg Angelica Linde n , Petropoulos Sophie , Deng Qiaolin , Stener-Victorin Elisabet

Introduction: Polycystic ovary syndrome (PCOS) is the leading cause of female infertility and is associated with high degree of comorbidities including type 2 diabetes and endometrial cancer. Hyperandrogenemia is a hallmark of PCOS and contributes to endometrial-related dysfunctions, including implantation failure and miscarriage. Whether cellular heterogeneity contributes to the functioning of the endometrium is not previously studied. Therefore, the aim is to reveal cell-typ...

ea0090p262 | Late-Breaking | ECE2023

Define cell-type-specific disease signatures regulating white adipose tissue of women with polycystic ovary syndrome

Li Congru , Eriksson Gustaw , Lu Haojiang , Vannay Alana , Lindgren Eva , Hirschberg Linden Angelica , Deng Qiaolin , Stener-Victorin Elisabet

White adipose tissue (WAT) is a dynamic and heterogeneous organ composed of different cell types involved in a wide array of biological processes. We know that women with polycystic ovary syndrome (PCOS) suffer from insulin resistance and type 2 diabetes which is associated with pathological white adipose tissue (WAT) function and expansion characterized by hypertrophic adipocytes, altered production and release of lipids and adipokines, and chronic low-grade tissue inflammati...

ea0081p190 | Reproductive and Developmental Endocrinology | ECE2022

The role of B cells in immune cell activation in polycystic ovary syndrome

Ascani Angelo , Torstensson Sara , Risal Sanjiv , Lu Haojiang , Teschl Sabrina , Eriksson Gustaw , Li Congru , Menezes Joana , Sandor Katalin , Svensson Camilla , Stradner Martin , Obermayer-Pietsch Barbara , Stener-Victorin Elisabet

Objective: Age-associated double negative (DN) B memory cells lacking surface expression of CD27 and immunoglobulin D (IgD) are associated with proinflammatory characteristics and higher disease activity in autoimmune diseases. We first characterized B cells phenotypes in women with and without polycystic ovary syndrome (PCOS). We then took an in vivo approach, transferring purified IgG extracted from serum of hyperandrogenic women with PCOS to mice to establish wheth...

ea0081ep910 | Reproductive and Developmental Endocrinology | ECE2022

Developmental programming by maternal androgen excess is mediated by androgen receptor pathways

Lu Haojiang , Li Congru , Pei Yu , Eriksson Gustaw , Pui Han-Pin , Risal Sanjiv , Torstensson Sara , Ascani Angelo , Lindgren Eva , Ohlsson Claes , Benrick Anna , Stener-Victorin Elisabet , Deng Qiaolin

Introduction: The hyperandrogenic in utero environment in pregnant women with polycystic ovary syndrome (PCOS) can affect embryo development and impair offspring health at adult age. Moreover, long term hyperandrogenic exposure also leads to unfavored changes to the mothersÂ’ reproductive physiology, leading to miscarriage, preterm delivery, and perinatal mortality. The underlying mechanism(s) of pregnancy complications associated with PCOS and the consequence of ...

ea0090rc11.3 | Rapid Communications 11: Late Breaking | ECE2023

Mapping endometrial cell-type-specific disease signatures and endometrial organoids in polycystic ovary syndrome

Eriksson Gustaw , Li Congru , Risal Sanjiv , Pui Han-Pin , Torstensson Sara , Linden Angelica Hirschberg , Petropoulos Sophie , Deng Qiaolin , Stener-Victorin Elisabet

Women with polycystic ovary syndrome (PCOS) suffer from reduced fertility linked to implantation failure and miscarriage, as well as endometrial cancer, all associated with endometrial dysfunction. We hypothesize that cell-type-specific endometrial dysfunction in insulin-resistant and hyperandrogenic women with PCOS contributes to their endometrial dysfunction and that treatment aimed at improving insulin sensitivity and decreasing androgen excess has the potential to reverse ...

ea0081p189 | Reproductive and Developmental Endocrinology | ECE2022

Is there a link between polycystic ovary syndrome and transgenerational transmission of a reproductive and metabolic function in male offspring?

Risal Sanjiv , Li Congru , Luo Qing , Fornes Romina , Manti Maria , Lu Haojiang , Eriksson Gustaw , Ohlsson Claes , Lindgren Eva , Crisosto Nicolas , Maliqueo Manuel , Echiburu Barbara , Recabarren Sergio , Sir Petermann Teresa , Benrick Anna , Brusselaers Nele , Qiao Jie , Deng Qiaolin , Stener-Victorin Elisabet

Our previous study showed that polycystic ovary syndrome (PCOS)-like reproductive and metabolic phenotypes induced by maternal dihydrotestosterone (DHT)-exposure, can be passed on in mice from mothers (F0) to daughters (F1), granddaughters (F2), and even to great-granddaughters (F3). The female transmission is independent of diet-induced obesity and is mediated by transcriptional and mitochondrial perturbations of oocytes accompany. ...