Searchable abstracts of presentations at key conferences in endocrinology

ea0016p740 | Thyroid | ECE2008

Serum ghrelin levels are increased in hypothyroid patient and become normalized after L-thyroxin treatment

Gjedde Signe , Vestergaard Esben Thyssen , Gormsen Lars Christian , Riis Anne Lene , Rungby Jorgen , Moller Niels , Weeke Jorgen , Jorgensen Jens Otto

Context: An interaction between gut-derived ghrelin, which is implicated in the regulation of short- and long-term energy balance, and thyroid function has previously been reported in patients with hyperthyroidism, in whom ghrelin levels are reversibly suppressed. In the present study, we measured total serum ghrelin levels and pertinent metabolic indices in hypothyroid patients before end after L-thyroxin replacement.Patients and methods:...

ea0014p210 | (1) | ECE2007

Effects of physiological bell-shaped elevations of free fatty acids on glucose metabolism and insulin sensitivity in humans

Gormsen Lars , Nielsen Charlotte , Jessen Niels , Vestergaard Esben , Christiansen Jens , Jørgensen Jens , Møller Niels

Background: Physiological elevations of free fatty acids (FFAs) occur in a dynamic bell-shaped fashion lasting some hours, e.g. nocturnally and during exercise. In order to define the metabolic role of physiological elevations in relation to diurnal fluctuations in insulin sensitivity, the present study was designed to identify the metabolic effects of a dynamic 4 hour elevation of FFAs during a glucose clamp.Materials and methods: 8 lean, healthy men we...

ea0014p67 | (1) | ECE2007

Intravenous constant ghrelin infusion in healthy young men: sustained cardiovascular effects of supraphysiological ghrelin levels

Vestergaard Esben Thyssen , Andersen Niels Holmark , Hansen Troels Krarup , Rasmussen Lars Melholt , Moller Niels , Sorensen Keld , Sloth Erik , Christiansen Jens Sandahl , Jorgensen Jens Otto Lunde

Objective: The short-term cardiovascular effects of continuous ghrelin infusion in healthy humans remain to be studied.Methods: Fifteen healthy, young and normal-weight men volunteered to participate in a randomized double-blind, placebo-controlled cross-over study. The local ethics committee approved the study. We used a constant infusion of human ghrelin at a rate of 5 pmol/kg body weight per minute for 180 minutes and measured peak left ventricular my...