Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep886 | Growth hormone IGF axis - basic | ECE2017

Nodular thyroid disease in acromegaly: cohort of 69 patients at a single institution

Alvarez-Escola Cristina , Gonzalez Diego Meneses , Dominguez Oscar Moreno , de la Morena Lucrecia Herranz

Materials and methods: The aims were to evaluate the frequency of nodular thyroid disease (NTD) in acromegalic patients and to correlate clinical and metabolic features with disease activity and other. We conducted a cross-sectional study including retrospectively 69 acromegalic patients attending to an University Hospital in Madrid, Spain between 1980 and 2016. Mean age was 63 (32–92) years, 63.8% of patients were female. Mean age at diagnosis of acromegaly was 48 (11&#1...

ea0041gp66 | Clinical Case Reports | ECE2016

Secondary adrenal insufficiency and hypogonadotropic hypogonadism in a patient with advanced medullary thyroid carcinoma on treatment with vandetanib. May it have a pathogenic role?

Escola Alvarez , Dominguez Moreno , Salas Cardenas , Fernandez Castelo , Santamaria Lecumberri , Pena Elviro

Clinical case: We report the case of a 40-year-old woman, diagnosed with sporadic medullary thyroid carcinoma (MTC) treated with total thyroidectomy, cervical lymph node dissection and chemotherapy. During follow-up, cervical lymph node, lung, breast, bone and subcentimeter cerebellous affectation was observed. She started on Sunitinib, but withdrawal at 6 months due to severe inguinal inverse psoriasis. Then, treatment with vandetanib was started with good response. Tumor mar...

ea0032p712 | Neuroendocrinology | ECE2013

Effects of GH therapy in carbohydrate metabolism in spanish adults with GH deficiency

Andrea Parra Ramirez Paola , Perez Fernandez Laura , Fernandez Martinez Alberto , Grande Aragon Cristina , Alvarez-Escola Cristina

GH deficiency (GHD) in adults is characterized by a tendency towards fat mass gain and may predispose to type 2 diabetes mellitus.GH replacement (GHR) is associated with impaired insulin sensitivity shortly after starting therapy, reflected by increased fasting glucose and insulin levels. Available evidence suggests that concerns regarding glucose intolerance in patients receiving long-term GHR have not been substantiated. However, several environmental and lifestyle-related f...

ea0029p374 | Clinical case reports - Pituitary/Adrenal | ICEECE2012

Childhood onset hypopituitarism and central apnea: looking beyond hormonal replacement

Fernandez Martinez A. , Olivar Roldan J. , Campos A. , Lapunzina P. , Rodriguez Sanchez A. , Alvarez Escola C.

Introduction: Childhood-onset hypopituitarism is an uncommon yet increasingly diagnosed disorder. As endocrinologists, we generally deal with the complexities of hormonal replacement and, when required, follow these patients to detect tumor recurrences. However, some causes of childhood- onset-hypopituitarism have comorbidities which can significantly increase morbi-mortality. We present the case of a 21-year-old girl who was diagnosed with ROHHAD syndrome.<p class="abstex...

ea0029p865 | Endocrine tumours and neoplasia | ICEECE2012

Non-medullary neuroendocrine carcinoma in the thyroid gland: a case-report

Alvarez-Escola C. , Riveiro Villanueva J. , Fernandez Martinez A. , Nistal M. , Castro A. , Barriuso J.

Introduction: Neuroendocrine lesions in the thyroid gland are uncommon. The differential diagnosis usually includes medullary thyroid carcinoma, paraganglioma and metastases. There are few non-conclusive reports of primary neuroendocrine carcinomas of the thyroid.Clinical case: A 49-year-old woman with a past medical history for familial hypercholesterolemia and right oophorectomy for mature teratoma with struma ovarii, was evaluated for a rapidly growin...

ea0029p1802 | Thyroid cancer | ICEECE2012

Coexistence of multiple lipomatosis and differentiated thyroid cancer: more than a coincidence?

Lecumberri B. , Parra P. , LLaro M. , Cardenas J. , Alvarez-Escola C. , Pallardo L.

Subcutaneous lipomas (SL) are the most common benign mesenchymal tumors with an estimated prevalence of 1%. They usually appear single, between 50–60 years of age, without gender differences. However, multiple lipomatosis (ML) occurs in 5–10% of patients, more frequently in men and almost 30% of them have family history of ML. Cytogenetic abnormalities are found in 50–80% of cases (at 12q15) and the presence of an underlying mitochondrial dysfunction has been su...

ea0081ep821 | Pituitary and Neuroendocrinology | ECE2022

Preference of acromegaly patients for treatment attributes in Spain

Fajardo-Montanana Carmen , Alvarez Escola Cristina , Biagetti Betina , Centeno Rogelio Garci a , Ciriza Raquel , Sanchez Laura , Diaz Marcos

Background: Acromegaly is a slowly progressive rare disease caused by an increase in growth hormone secretion that causes a subsequent rise in insulin-like growth factor (IGF-1), both contributing to the excessive growth of the extremities, soft tissues and organs, in addition to other comorbidities directly interfering with patient’s quality of life. Acromegaly patients are concerned about their disease and their treatments, however, publications about patient’s opi...

ea0029p1488 | Pituitary Clinical | ICEECE2012

Pegvisomant and cabergoline combination therapy in acromegaly

Bernabeu I , Alvarez-Escola C , Paniagua A , Lucas T , Pavon I , Cabezas Agricola J , Casanueva F , Marazuela M

Objective: Combination with cabergoline may offer additional benefits to acromegalic patients on pegvisomant monotherapy. We evaluated the safety and efficacy profile of this combination and investigated the determinants of response.Design: An observational, retrospective, cross-sectional, registry-based study.Patients and methods: Fourteen acromegalic patients (9 females), who were partially resistant to somatostatin analogs and o...

ea0020p282 | Clinical case reports and clinical reports | ECE2009

Breast metastases by medullary thyroid carcinoma: case report with an update

Chimenti Elisa Moya , Santamaria Beatriz Lecumberri , Antonio Rosado Sierra Jose , Barquiel Alcala Beatriz , Felipe Pallardo Sanchez Luis , Alvarez Escola Cristina

Introduction: Medullary thyroid carcinoma (MTC) commonly metastasizes to cervical lymph nodes, liver, lungs and bone. Metastatic lesions in the breast have been previously reported but they are extremely rare and to our knowledge, this is the first case in literature described on a male patient. We report a case of a 49-year-old man with a 23-year history of sporadic MTC with bone, liver and lung metastases treated with somatostatin analogues for 6 years, who developed a painf...

ea0016p406 | Neuroendocrinology | ECE2008

Malignant diseases in our patients with acromegaly

Moya Chimenti Elisa , Alvarez Escola Cristina , Lecumberri Santamaria Beatriz , Fernandez Alberto , Garcia Dominguez Maria , Felipe Pallardo Sanchez Luis

Background: Acromegaly, a chronic disease caused by excess secretion of growth hormone (GH), has been known to reduce patients life expectancy. This increase in morbility and mortality is not only due to cardiovascular, respiratory or cerebrovascular disorders, but also to an increased risk for cancer.Subjects and methods: The aim of this study was to describe the associated malignant diseases among our fifty acromegalic patients. Clinical features of th...