Searchable abstracts of presentations at key conferences in endocrinology

ea0063gp48 | Acromegaly and GH | ECE2019

Prolonged diagnostic delay in acromegaly is associated with long-term morbidity and excess mortality: data from a nationwide study

Esposito Daniela , Ragnarsson Oskar , Johannsson Gudmundur , Olsson Daniel S

Background: Clinical features of acromegaly develop insidiously and the diagnosis is often delayed. However, diagnostic delay (DD) in acromegaly has not been systematically investigated. Our primary aim was to investigate DD in a nationwide cohort of patients with acromegaly. Secondary aim was to study the impact of DD on morbidity and mortality.Methods: Adult patients diagnosed with acromegaly between 2001 and 2013 were identified in the Swedish Nationa...

ea0070aep65 | Adrenal and Cardiovascular Endocrinology | ECE2020

Patients with adrenal insufficiency have cardiovascular features associated with hypovolemia

Esposito Daniela , Johannsson Gudmundur , Ragnarsson Oskar , Pasquali Daniela

Context: Patients with adrenal insufficiency (AI) have excess mortality and morbidity, mainly due to cardiovascular diseases. The mechanisms for this is unclear.Objective: To assess cardiovascular structure and function in AI patients on conventional replacement therapy and after switching to once-daily, modified-release hydrocortisone (OD-HC).Methods: The analysis included 17 adult AI patients (11 with primary AI, 7 with secondary...

ea0070aep677 | Pituitary and Neuroendocrinology | ECE2020

Carpal tunnel syndrome is common in patients with undiagnosed acromegaly – a swedish nationwide study

Vouzouneraki Konstantina , Esposito Daniela , Mukka Sebastian , Granfeldt Daniel , Ragnarsson Oskar , Dahlqvist Per , Olsson Daniel S

Background: Carpal tunnel syndrome (CTS) is common in patients with acromegaly, with a reported prevalence of 19–64%. We have studied CTS in a large national cohort of patients with acromegaly, and the temporal relationship between the diagnosis of the two diseases.Methods: Retrospective nationwide cohort study including patients diagnosed with acromegaly in Sweden between 2005 and 2017. Patients with acromegaly were identified in the Swedish Natio...

ea0081rc4.6 | Rapid Communications 4: Pituitary and Neuroendocrinology 1 | ECE2022

Impact of diabetes on morbidity and mortality in patients with acromegaly

Esposito Daniela , Olsson Daniel S , Franzen Stefan , Gudbjornsdottir Soffia , Miftaraj Mervete , Natman Jonatan , Svensson Ann-Marie , Johannsson Gudmundur

Background: Diabetes is an important risk factor for cardiovascular morbidity and mortality but its impact on outcome in acromegaly is unknown.Methods: This was a nationwide, observational, matched-cohort study. Adult patients with acromegaly due to a pituitary adenoma were identified in the Swedish National Patient Registry between 1987 and 2020 and those with coexistent type 2 diabetes in the National Diabetes Registry and Drug Registry. Overall mortal...