Searchable abstracts of presentations at key conferences in endocrinology

ea0056p1080 | Thyroid (non-cancer) | ECE2018

EMPATHY: a new tool for identifying the most suitable thyroxin formulation in hypothyroid patients

Bellastella Giuseppe , Caputo Mariangela , Ida Maiorino Maria , Longo Miriam , Scappaticcio Lorenzo , Giugliano Dario , Esposito Katherine

Hypothyroidism therapy is based on the administration of appropriate dose of L-thyroxine (L-T4). Absorption of L-T4 takes place in the duodenum and upper tract of the small intestine (jejunum), is maximal when stomach is empty, and is affected by a number of gastrointestinal disorders, including Helicobacter pylori–related gastritis, as well as ingestion of drugs, dietary fibers, and herbal remedies. Failure to achieve a good control of disease may be due to malabsorption...

ea0049ep1121 | Female Reproduction | ECE2017

Natural history of autoimmune primary ovarian insufficiency progresses through several stages from normal ovary function to clinically overt ovary dysfunction

Bellastella Giuseppe , Casciano Ofelia , Barrasso Mariluce , Maiorino Maria Ida , Giugliano Dario , Esposito Katherine , Scappaticcio Lorenzo , Bellis Annamaria De

Context: Women with autoimmune Addison’s disease with normally ovulatory cycles but positive for steroid cells antibodies (StCA) have been considered at risk of premature ovarian insufficiency (POI).Design: Thirty-three women younger than 40 years, with subclinical-clinical Addison’s disease but with normally ovulatory menses, were followed-up for 10 years to evaluate the long-term time-related variations of StCA, ovarian function and follicula...

ea0032p659 | Male reproduction | ECE2013

Effects of testosterone replacement therapy on hepcidin levels in young hypogonadal men

Palumbo Vincenzo , Esposito Dario , Visconti Daniela , Topa Adele , Rezza AnitaLa , Bellastella Giuseppe , De Bellis Annamaria , Agostino Sinisi Antonio

Erythrocytosis is a frequent adverse event associated with testosterone (T) administration in aged hypogonadal men, but the mechanisms involved remain poorly understood. T administration to aged men reduced hepcidin (Hpc) levels, a cytokine regulating iron availability, suggesting a potential role in deregulated erythropoiesis. Aim of present study was to evaluate the effects of T replacement therapy on Hpc levels in young hypogonadal men.Methods: Fifty-...

ea0022p543 | Male reproduction | ECE2010

Serum INSL3 dynamics in young men with congenital hypogonadotropic hypogonadism treated with gonadotropins

Bellastella Giuseppe , Esposito Dario , Maione Luigi , Visconti Daniela , Palumbo Vincenzo , De Bellis Annamaria , Bellastella Antonio , Sinisi Antonio Agostino

Insulin-like factor 3 (INSL3) is produced by Leydig cells. In boys, the levels of INSL3 rise at pubertal stage P2 and further increase throughout puberty in close correlation with T and LH concentrations. In men with hypogonadotropic hypogonadism (HH) INSL3 levels have been found very low and increased after short-term hCG treatment. Whether FSH plays a role in regulating INSL3 secretion is questioned. Aim of this study was to evaluate serum INSL3 levels during long-term hCG a...

ea0016oc5.3 | Reproduction | ECE2008

Prokineticin-2 and prokineticin receptor-2 gene analysis in men with Kallmann syndrome or normosmic hypogonadotropic hypogonadism

Sinisi Antonio Agostino , Asci Roberta , Bellastella Giuseppe , Esposito Dario , Maione Luigi , Visconti Daniela , Bellastella Antonio , Jolascon Achille

Prokineticins (PK1 and PK2) are peptides regulating multiple biological processes through two G-protein coupled receptors, PK-R1 and PK-R2. PK2/PKR2 signalling is critical for neurogenesis of olfactory bulb and GnRH migration. Mutant mice lacking PKR2 have abnormal development of olfactory bulb and reproductive system atrophy, suggesting that these genes may be novel candidate for Kallmann syndrome (KS) in humans. Recently, mutations in PK2 and PKR2 genes have been found in ne...