Searchable abstracts of presentations at key conferences in endocrinology

ea0022p663 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Sellar lesions in Ollier disease: case report and a review of the literature

Jaffrain-Rea Marie-Lise , Giangaspero Felice , Esposito Vincenzo , Cantore Giampaolo

Ollier disease (OD) is a rare disease, with multiple enchondromas localized in the metaphysis of long bones, hands and feet, developing in the first decade of life, with potential malignant transformation into chondrosarcomas. OD is usually sporadic and probably caused by post-zygotic genetic alterations leading to mosaicism. A PTH/PTHrP receptor type 1 (PTHR1) gene mutation is present in some cases.Case report: A 21-years old male patient was referred t...

ea0037ep784 | Pituitary: clinical | ECE2015

Recurrence of GH-secreting pituitary adenomas during puberty in children with germline AIP mutations: a clinical challenge

Filipponi Silvia , Esposito Vincenzo , Daly Adrian F , Beckers Albert , Jaffrain-Rea Marie-Lise

Germline AIP mutations (AIPmut) predispose to young onset somatotroph pituitary adenomas (GHPA) and gigantism. AIPmut GHPA are often aggressive and resistant to pharmacological treatment, which may be especially challenging in the paediatric setting. We report our experience with two young Italian AIPmut male patients with incipient gigantism due to childhood pituitary macroadenomas, who both experienced recurrent ...

ea0035p835 | Pituitary Basic (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

AIP expression in non-functioning pituitary adenomas is strongly associated with the gonadotroph phenotype but not with tumour aggressiveness

Rotondi Sandra , Oliva Maria Antonietta , Esposito Vincenzo , Ventura Luca , Giangaspero Felice , Alesse Edoardo , Jaffrain-Rea Marielise

The aryl hydrocarbon receptor interacting protein gene has been mainly involved in the pathogenesis of GH/PRL-secreting pituitary adenomas (PA). We wished to study the significance of AIP expression in clinically non-functioning PA (NFPA).Material and methods: 48 NFPA -27 gonadotroph (GnPA), 21 null cell (ncPA) – were studied for AIP, βFSH and cyclin D1 expression by real-time RT-PCR (qRT), compared with four normal post-mortem pituitaries (NP)...

ea0014p581 | (1) | ECE2007

Effects of successful transsphenoidal surgery on cardiovascular function in elderly acromegalics

Minniti Giuseppe , Moroni Carlo , Esposito Vincenzo , Cassone Rosario , Cantore Gianpaolo , Jaffrain-Rea Marie Lise

Background: Transsphenoidal surgery (TSS) is able to determine the biochemical remission of acromegaly in 45%–80% of the patients, thereby inducing an improvement of cardiovascular function and glucose metabolism. Only 3–5% of acromegalics are diagnosed over 65-years-old, so few data are available about post-operative cardiovascular and metabolic changes in this group.Patients and Methods: Fifteen acromegalic patients ≥65 years-old who un...

ea0032p659 | Male reproduction | ECE2013

Effects of testosterone replacement therapy on hepcidin levels in young hypogonadal men

Palumbo Vincenzo , Esposito Dario , Visconti Daniela , Topa Adele , Rezza AnitaLa , Bellastella Giuseppe , De Bellis Annamaria , Agostino Sinisi Antonio

Erythrocytosis is a frequent adverse event associated with testosterone (T) administration in aged hypogonadal men, but the mechanisms involved remain poorly understood. T administration to aged men reduced hepcidin (Hpc) levels, a cytokine regulating iron availability, suggesting a potential role in deregulated erythropoiesis. Aim of present study was to evaluate the effects of T replacement therapy on Hpc levels in young hypogonadal men.Methods: Fifty-...

ea0014p153 | (1) | ECE2007

The beta-HLH transcription factor neurogenin-2 is preferentially expressed by secreting pituitary adenomas

Fratticci Amato , Grieco Fabio , Spilioti Cristina , Giangaspero Felice , Esposito Vincenzo , Santoro Antonio , Ventura Luca , Alesse Edoardo , Jaffrain-Rea Marie-Lise

Beta-HLH transcription factors are involved in the ontogenesis of neural/neuroendocrine cells, and may play a role in the pathogenesis of neuroendocrine tumours. Neurogenin 2 (Ngn2) is expressed by the developing mouse pituitary. After preliminary data indicating its expression in the normal human pituitary, we have studied its phenotypic expression in normal and adenomatous pituitary tissues.Methods: Fifty-two pituitary adenomas (PA) – 23 clinicall...

ea0081rc4.1 | Rapid Communications 4: Pituitary and Neuroendocrinology 1 | ECE2022

Immunotherapy in a non-functioning metastatic pituitary neuroendocrine tumor. An encouraging case report

Feola Tiziana , Gianno Francesca , Verrico Monica , Giangaspero Felice , Tomao Silverio , Colonnese Claudio , Esposito Vincenzo , Isidori Andrea , Minniti Giuseppe , Jaffrain-Rea Marie-Lise

Introduction: Metastatic pituitary neuroendocrine tumors (PitNETs) or pituitary carcinomas are rare and challenging conditions. We present a recent and encouraging observation of a temozolomide (TMZ)-resistant clinically non-functioning metastatic PitNET showing a remarkable response to the anti-PDL1 drug Pembrolizumab.Case presentation: A 57-years-old man had transsphenoidal surgery in November 2012 for a large non-functioning intra/suprasellar mass rev...

ea0035p834 | Pituitary Basic (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

Expression of peroxisome-proliferator activated receptor α in pituitary tumours

Rotondi Sandra , Modarelli Alessio , Rostomyan Lilya , Oliva Maria Antonietta , Esposito Vincenzo , Ventura Luca , Arcella Antonietta , Alesse Edoardo , Beckers Albert , Jaffrain-Rea Marielise

Peroxisome-proliferator activated receptors (PPARs) are involved in a number of neoplasia. PPARα (PPARα) is a partner of the aryl hydrocarbon receptor interacting protein (AIP), which is involved in the pathogenesis of pituitary adenomas (PA). We wished to investigate the potential expression and biological significance of PPARα in PA, especially in GH/PRL-secreting tumours.Material and methods: A large series of PA was collected (n</e...

ea0032p529 | Endocrine tumours and neoplasia | ECE2013

Familial malignant paraganglioma is long-term stabilized with the tyrosine-kinase inhibitor sunitinib

Ramundo Valeria , Marciello Francesca , Del Prete Michela , Marotta Vincenzo , Esposito Raffaella , Chiara Carratu Anna , de Luca di Roseto Chiara , Colao Annamaria , Faggiano Antongiulio

Introduction: Paragangliomas are neuroectodermal tumors that arise from adrenal medulla or extra-adrenal ganglia and are characterized by high vascularisation. A high rate of these tumours is genetically inherited. For malignant paragangliomas, chemo- and radio-therapy are potentially effective, but tumor response is of short duration and patient prognosis is quite poor. Sunitinib is a tyrosine-kinase inhibitor, targeting VEGFR1, -2, PDGFRα, -β, RET and c-Kit. Recent...

ea0073pep13.1 | Presented ePosters 13: Pituitary and Neuroendocrinology | ECE2021

Factors associated with Aryl hydrocarbon Interacting Protein (AIP) expression in gonadotroph pituitary neuroendocrine tumours (Pit-NETs)

Polidoro Michela A. , Feola Tiziana , Gianno Francesca , Palumbo Valeria , Arcella Antonietta , Morace Roberta , De Angelis Michelangelo , Giangaspero Felice , Esposito Vincenzo , Jaffrain-Rea Marie-Lise

IntroductionAIP is a predisposing gene for GH/PRL-secreting PitNETs. Clinically non-functioning PitNETs (NFPT) occasionally occur in the setting of AIP germline mutations, sometimes arising from Pit-1 lineages. However, AIP overexpression has been observed in unselected NFPT and associations with the gonadotroph phenotype and/or tumour aggressiveness were suggested. We wished to evaluate the significance of AIP expression in gonadotroph tumours defined b...